Blood : a study in general physiology / by Lawrence J. Henderson.

  • Lawrence Joseph Henderson
Date:
1928
Catalogue details

Licence: In copyright

Credit: Blood : a study in general physiology / by Lawrence J. Henderson. Source: Wellcome Collection.

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    geneity and of changing acidity of the hemoglobin mole¬ cule : A[BHC03] = 2.08 millimoles per liter, ApH = 0.028, A [BP] c = 0.88 millimole per liter, A[BP]S = 0.09 millimole per liter, A[BP]b = 0.97 millimole per liter. These values indicate that the true buffer action of all the blood proteins, a[BP]b, is less than half that of carbonic acid, a[BHC03]. A similar consideration based upon less accurate data, and, like this, only roughly approximate, because of ignorance of the acid-base relations within the cell and of the laws of heterogeneous equilibrium, led me to the conclusion that an unknown factor within the cells supplements simple buffer action and facilitates the transport of carbonic acid.72 This unknown factor is the effect of oxygenation upon the acid properties of hemo¬ globin. The problem may be clarified by a consideration of the composition of the blood of A.V.B. under several differ¬ ent conditions as defined in table 5. In this table, column I gives the composition of arterial blood, column II that of venous blood, column III that of blood having the oxygen content of arterial blood but the same value of pC02 as venous blood, while column IV gives the value of BPC for blood having the same value of Hb02 as arterial blood and the same value of pHc as venous blood. 72 L. J. Henderson, Journal of Biological Chemistry, VII, 29 (1909).
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