Blood : a study in general physiology / by Lawrence J. Henderson.

  • Lawrence Joseph Henderson
Date:
1928
Catalogue details

Licence: In copyright

Credit: Blood : a study in general physiology / by Lawrence J. Henderson. Source: Wellcome Collection.

    144/434 page 118
    But we may deduce from equation 3 that the quantity [BHC03]s is a function of pC02 and of p02. Therefore, we have also [H+]s = fa (pC02, p02). (5) Again, according to Van Slyke, Wu, and McLean, the Donnan r, as well as v, the volume of the red cells, is a function of hydrogen ion concentration and of the degree of oxygenation of hemoglobin, therefore, since the two latter variables are both functions of pC02 and of p02 (equations 4 and 5), we have r — f4 (pC02,P02), (6) v = f5 (PC02,p02), (7) and similarly for all the other physiological variables. The five equations, 3, 4, 5, 6, and 7, state as abstractly as possible the facts discussed in the preceding lectures. They include seven variables—pC02, p02, total carbonic acid, total oxygen, the hydrogen ion concentration, and the quantities r and v—one less than the number of com¬ ponents of the system, and they suffice for a complete ap¬ proximate characterization of any specimen of mamma¬ lian blood. If it were not for certain simplifying assumptions such as that of a general law defining the value of r, with or without constant differences for the different anions, and that of osmotic equilibrium, the case would be different. The necessary equations would then be six in number, like the number of components of constant mass, and the total number of variables would be eight. It seems possi¬ ble that another equation defining independent variations in the values of the several r’s may soon be necessary and, in that case, the number of equations will, in fact, be six, the number of variables eight. It is evident that if we possessed complete information concerning the activities of each of the six components of constant mass in terms of the two variable components
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