Blood : a study in general physiology / by Lawrence J. Henderson.

  • Lawrence Joseph Henderson
Date:
1928
Catalogue details

Licence: In copyright

Credit: Blood : a study in general physiology / by Lawrence J. Henderson. Source: Wellcome Collection.

    206/434 page 178
    Under these circumstances the change in total carbonic acid of the respiratory cycle in blood must be due almost exclusively to the oxygen effect upon the affinity of hemo¬ globin for base, since at constant hydrogen ion concentra¬ tion hemoglobin can exert no true buffer action, and with the small change in hydrogen ion concentration in serum the huffier action of the serum proteins is small. TABLE 14. Individual Mean A.Y.B. Rest (1) 0.70 A.V.B. Rest (2) 0.70 A.V.B. Rest (3) 0.71 C.V.C. Rest 0.66 A.Y.B. Work 0.67 Normal Man 0.69 Pernicious Anemia (1) 0.61 Pernicious Anemia (2) 0.73 Pernicious Anemia (3) 0.63 Pernicious Anemia 0.66 Polycythemia 0.59 Polycythemia 0.59 Myxedema (1) Myxedema (2) Myxedema (3) 0.65 [0.99] 0.62 Myxedema 0.64 Horse (Man Slyke, Wu, and McLean) 0.75 Horse 0.75 Turtle 20° 0.57 Turtle 37.5° 0.58 Turtle 0.58 All Values 0.66 Another deduction from the same fact is that the effect upon the hydrogen ion concentration of the addition of one equivalent of oxygen is approximately equal to that of the addition of 0.7 equivalent of carbonic acid. This appears to be a roughly constant relation for different specimens of blood, as shown in table 14. In this table there will be found, for all cases thus far studied, the value of the respiratory quotient line which approxi¬ mately corresponds with the scale of pHc. The mean values are also indicated in the table, one datum from a case of myxedema, which was very imperfectly studied
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