Note on the effect of various substances in destroying the activity of cobra poison / by T. Lauder Brunton and J. Fayrer.

  • Lauder Brunton
Date:
[1878]
Catalogue details

Licence: Public Domain Mark

Credit: Note on the effect of various substances in destroying the activity of cobra poison / by T. Lauder Brunton and J. Fayrer. Source: Wellcome Collection.

    4/10 (page 468)
    4.54 P.M. Shivering. Head fallen over. 5 p.m. Fallen over. Slow paralysis creeping over limbs. Respira- tion slow. Gets up, rolls over again. On touching the eye the eyelid moves. Reflex not gone from the ear. 5.6 p.m. Fallen over. Paralysed. Reflex nearly gone, still slight from ear. Pupils dilated. 5.9 p.m. Convulsions. Pupils become normal again. Respiration very slow—thirteen per minute. 5.20 p.m. Tries to rise. Very feebly. 5.22 ,, Fallen quite over. 5.23 ,, In same condition. Makes feeble efforts to rise. Pupils dilated again. 5.27 p.m. Again tries to rise. Micturition. 5.29 „ Convulsions. 5.30 „ Dead. No local symptoms, i.e., no extravasation about tho puncture. No congestion of stomach or bowels. Stomach empty. Blood coagulated after death. Injected at 3.39 p.m. Died at 5.30 p.m. Death in one hour and fifty-one minutes. The following experiments show the effect of chloride of gold in completely destroying the cobra poison. Experiment IV. March 7th, 1878. Three mgms. of cobra poison, mixed with 1 grain of chloride of gold, dissolved in 40 grain measures of water, injected into the hip of a white guinea-pig, weighing 18 oz., at 3.50 p.m. 4.10 p.m. Crouching quietly in comer of box. Tremor, perhaps fright. 4-15 p.m. Seems uneasy; crouching in corner. No other change. Recovered without any bad symptoms. . Experiment V. March 14th. In this experiment a very large dose of poison was used. 1 30 mgms. of cobra poison, mixed with 1| cub. centime, of a 10 per cent, solution of chloride of gold, were injected into a guinea-pig weighing 20 oz., at 3.30 P.M. 75 cub. centims. of water was used to wash out glass, and t len injected. The poison and the chloride form a yellow creamy precipi- tate. , 3.30 p.m. Began to jerk and twitch immediately, excited, running about the box. . , , 3.35 p.m. Crouching in corner, twitching, but not otherwise affecte .