Quinine prophylaxis and latent malaria infection / by I.J. Kligler.

  • Israel Jacob Kligler
Date:
1923
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Licence: Public Domain Mark

Credit: Quinine prophylaxis and latent malaria infection / by I.J. Kligler. Source: Wellcome Collection.

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    QUININE PROPHYLAXIS AND LATENT MALARIA INFECTION. BY I. J. KLIGLER, M.A., B.S., PHD. | Controller, Malaria Research Unit, Department of Health, Palestine. Paper presented at a Meeting of the Royal Society of Tropical Medicine and Hygiene, Thursday, 18th October, 1923. During the war and since, evidence has been accumulated which shows that quinine prophylaxis is not efficacious in preventing malaria epidemics. In the last two years, in Palestine, we have obtained ample proof in confirmation of the results of other observers. There is, however, one effect of quinine prophylaxis which has not been sufficiently empha- sised, namely, its tendency to mask infections, or maintain a condition of latent infection. This note deals with a series of such infections in two highly malarious areas—Athlit, in Phoenicia, and Hin Harod, in the Valley of Jezreel. Athlit is a small settlement surrounded on two sides by extensive swamps. In July, 1922, a company which had obtained a salt concession began its operations near the village. A tent camp was set up within afew hundred metres of the swamp. Before three weeks had passed a serious epidemic of malaria broke out. Heroic measures were immediately adopted. All the men were given heavy doses (2 grams dailv) of auinine for five days, and then $ gram daily during the entire NAAT no. ig Cock. 18, 1423) EE 22200154111
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