Heparin / Boots.

  • Boots Pure Drug Company
Date:
[between 1950 and 1959?]
Catalogue details

Licence: Public Domain Mark

Credit: Heparin / Boots. Source: Wellcome Collection.

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    HEPARIN—BOOTS HEPARIN, a sodium salt of a mucoitin polysulphuric acid, first discovered by Howell and McLean in 1916, is the granular substance present in the mast cells which are distributed in the walls of the vascular and reticulo-endothelial systems; it is the normal physiological anticoagulant of the human blood. A- detailed account of the chemistry and mode of action of heparin will be found in the work of Jorpes (Heparin in the Treatment of Thrombosis, London, 1946) to whom we owe.much of our Knowledge of the subject. Heparin is the ideal anticoagulant; experimental work on rabbits has shown that these animals can tolerate, without any serious effects, repeated doses far in excess of those normally used clinically. This is in marked contrast to many of the syn- thetic anticoagulants, large doses of which tend to cause severe internal hemorrhage. Heparin is heat-stable, is not readily destroyed by natural enzymes or chemicals, and is virtually free from toxic effects. The effects of overdosage can be readily neutralized by Injection of Protamine Sulphate. STANDARDIZATION Heparin—Boots is standardized, in our own Pharmacological Laboratories, in terms of International Units, one I.U. being the specific activity possessed by 0-0077 mg. of the Standard Preparation at present in use. Before issue, Heparin—Boots is required to pass a strict test for freedom from pyrogens.
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