The resolution of hyoscine and its components, tropic acid and oscine / by Harold King.

  • King, Harold
Date:
1919]
Catalogue details

Licence: Public Domain Mark

Credit: The resolution of hyoscine and its components, tropic acid and oscine / by Harold King. Source: Wellcome Collection.

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    30 c.c. of 10 per cent, hydrochloric acid. The rotation was followed as in the case of the hydrobromide. Initial reading . After 2 hours' boiling — 55' ; l = 2-dcra. 8 On removal of the Z-tropic acid (O’15 gram; m. p. 124—125°) by ether, the acid aqueous solution was optically inactive, and when evaporated to dryness with absolute alcohol gave 0‘13 gram ot <7Z-oscine hydrochloride crystallising in minute, rectangular plates, or associated together in fern-like growths. It was con¬ verted into the picrate, which crystallised in small, flattened rhombs or tablets melting and decomposing at 231°. A mixture with pure cZZ-oscine picrate, which crystallises similarly and melts and decomposes at 237—238°, melted intermediately at 232°. In conclusion, the author desires to express his warmest thanks to Dr. Pyman for his advice and criticism throughout the course of the work. The Wellcome Chemical Research Laboratories, London, E.C. [Received, March 26th, 1919.] PRINTED IN GREAT BRITAIN BT R. CLAT AND SONS, LTD., BRUNSWICK STREET. STAMFORD STREET. S.K 1. AND BDNGAI, SUFFOLK