Studies on the etiology of blackwater fever / I.J. Kligler.

Israel Jacob Kligler

Date:: 1923

Credit: Studies on the etiology of blackwater fever / I.J. Kligler. Source: Wellcome Collection.

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$T.D by. Vebag. p63 sth * ; ee ft f £ 7 A Reprinted from Tor AMBRICAN.JOURNAL OF TROPICAL MEDICINE Vol. III, No. 3, May, 1923 Se $65 \, af ’ o ; & a (ie LIBRARY }) rer: > & ‘WELLCOME INSTITUTE | | LIBRARY | Col! welTROmec | S ON THE ETIOLOGY OF BLACKWATER FEVER al I. J. KLIGLER Laboratory, Rothschild Hospital, Jerusalem Received for publication March 16, 1923 Despite numerous investigations on blackwater fever the eti- ology of this disease is still unknown. One school of investi- gators believes that quinine and malaria are the factors responsible for the disease. The other school contends that there are two distinct disease conditions, one associated with malaria which they designate as quinine hemoglobinuria; the other specific blackwater fever. The first mentioned condition may be pro- duced in cases of chronic malaria by even minute doses of quinine, while the second has a specific etiology, the nature of which is still unknown. The mechanism of the production of hemoglobinuria during malaria has been studied extensively by Barratt and Yorke (1909). They found that quinine, hydrochloric acid, and sodium hydroxide will induce the necessary hemolysis, but that during life quinine never reaches a concentration sufficient to cause hemolysis. The anuria they attribute to a mechanical blocking of the kidney tubules by the deposited hemoglobin. In the course of the last year we have had occasion to study 4 eases of clinical blackwater fever. Certain experiments were made with the hope of obtaining facts with regard to the cause for the appearance of blood in the urine. The purpose of this paper is to report briefly such observations as appear to be of interest. 7 ae ess Nee RELATIONS TO MALARIA AND QUININE All the cases gave a history of malaria. Malaria parasites were found in the blood of each either before or after the attack of hemoglobinuria. During it no parasites were found. Three WT IIL / 22200154086 | |$

Studies on the etiology of blackwater fever / I.J. Kligler.

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