Upon an anti-cholera serum / by Allan Macfadyen, M.D. Edin, Fullerian professor of physiology, Royal Institution.

  • Macfayden, Allan, 1860-1907
Date:
[1906?]
Catalogue details

Licence: In copyright

Credit: Upon an anti-cholera serum / by Allan Macfadyen, M.D. Edin, Fullerian professor of physiology, Royal Institution. Source: Wellcome Collection.

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    adopted, but also the practicability of raising to a marked degree the anti-endotoxic value of the serum. It remains to add that the goat’s serum likewise possessed agglutinative and bacteriolytic properties—e.g., cubic centimetre of the serum agglutinated the cholera bacilli and i>th cubic centimetre gave Pfeiffer’s reaction. The experiments in this direction were not carried further than was necessary to demonstrate the existence of these bodies. Conclusions. The experiments show :—1. That acutely toxic cell juices possessing active immunising properties can be obtained from the cholera organism by the method employed. 2. That an antibody can be produced for that primary poison which exists as an integral constituent of the cholera bacillus—a matter upon which there have been considerable dispute and difference of opinion. 3. That the anti-endotoxic power of the serum can be raised to a marked degree—a matter of equal importance. 4. That the serum in addition to its anti- endotoxic possessed agglutinative and bacteriolytic pro¬ perties. 5. That in the case of the cholera organism there exists an intimate relationship between its virulence and toxicity. 6. That the cholera endotoxin obtained under the conditions described is thermolabile, being readily destroyed at 55° and 60° C. King’s College, London. Printed at The Lancet Office, 423, Strahd, W.C.
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