The newer remedies. A reference manual for physicians, pharmacists & students / by Virgil Coblentz.

  • Coblentz, Virgil, 1862-1921
Date:
1896
Catalogue details

Licence: Public Domain Mark

Credit: The newer remedies. A reference manual for physicians, pharmacists & students / by Virgil Coblentz. Source: Wellcome Collection.

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    CREOSAL. A compouud obtained by heating a mixture of equal parts of tannin and creosote at 80® C., then adding phosphorus oxycliloride and continuing the heat until no more gas is evolved. The mass is mixed with dilute sodium hydrate solution, whereby creosal separates ; this is well washed and dried. Creosal is a hygroscopic, dark- brown powder, wliich is readily soluble in water, alcohol and glycerin. Creosal is recommended in powder form or aqueous solution in treatment of inflammation of the air passages. C R EOSO L. C0II3CII3 (OH) (O.CII3). Synonyms: IIomo-Pyrocatechiu-Metyl Ether; Ilomoguaiacol. Tills occui’s, along with guaiacol, as a constituent of beech-wood tar creosote. It is an oily-like liquid, of aromatic odor, boiling at 220® C. (428® F.), only slightly soluble in water. Kecommended as an antiseptic. CREOSOTE-CALCIUM-CHLORHYDRO-PHOSPHATE. A white, syrupy mass, consisting of a mixture of creosote carbonate and calcium- chlorhydro-phosphate. Kecommended in phthisis and scrofula. Dose 5 to 10 grains. Creosote-calc.-chlorhyd.-phosp 5 to 10 Gm. Mucilag. chondri 15 “ 01. Amyg. dulc 25 “ Syr. Tolutani 25 “ Aq. flor. aurant 75 “ M. f. emulsio. Dose two teaspoonfuls daily. CREOSOTE CARBONATE. See under Guaiacol. .CH3 CREOSOTIC ACID. CeHs <Oll coon Synonyms; Cresotinic Acid; Oxytoluic Acid; Homosalicylic Acid. This may exist as an ortho, meta, or para modification, hence is frequently desig- nated ill the plural, as creosotic acids. These bear the same relation to toluene (CeHsCHs) that salicylic acid bears to benzene (CgHg), being then hydroxytoluic acid. They are prepared from the sodium cresylates by a process (Kolbe’s) analogous to that used in the manufacture of salicylic acid. The para compound, which crystallizes in white needles melting at 151°C. (303.8°F.), is the only one that is employed in medicine, in the form of a sodium salt. CREOSOTOL. See under Guaiacol. CRESALOLS. C9H4 (OH) C02C6n4.CH3. Synonyms: Cresol Salicylates; Cresol Salols, Ortho-, meta-, and para-cresalol are the salicylic esters of the cresols, analogous to betol and salol, and prepared in a similar manner. A mixture of sodium salicylate and cresylate, in molecularT)roportions, is heated with phosphorus oxychloride; either ortho, meta, or para cresalol is obtained according to the sodium salt used. These three isomeric cresalols form bulky, white, crystalline powders, insoluble in water, soluble in alcohol and ether, and sparingly so in oils. The ortho-cresalol melts at 35“ C. (95° F.), the meta-cresalol at 74° C. (165.2° F.), and the para-cresalol at <^° C. (102.2° F.) Externally the cresalols are recommended as antiseptic dusting-powders, also in- ternally as a substitute for salol, being split up in the system into cresol and salicylic acid. CRESOL SALICYLATE. See Cresalols. CRESOL SALOLS. See Cresalols. C R ESO L, or T H E C R ESO LS. Cen4 < {3]; Synonyms; Cresylic Acid; Meta-Cresol; Kresol; Meta-Phenol. The Cresol-s, of which three isomerieles exist (ortho-meta-para) are homologues of phi nol and derivatives of toluene. They are obtained by the fractional distillation of tha. portion of coal-tar oil which comes over between 19U°—210° C. The three isomer- ides are exceedingly difficult to separate; of these the meta-cresol is the most power- ful antiseptic. All the cresols possess a creosote-like odor, their antiseptic properties are superior to those of carbolic acid and they are far less poisonous. The only hin- drance to their general employment is theirinsolubility in water. During the past few years various soluble preparations introduced have again brought them into notice; in these, the cresol (o-m-p) is rendered soluble by the addition of soap {Sapocarbol, Lysol, Creolin, Phenolin, Saimcresol, etc.), or an alkali forming soluble cresylates (Solved. Solutol) or by couversiou into soluble sulphonic acid derivatives {.Artmann's Creolin).