The newer remedies. A reference manual for physicians, pharmacists & students / by Virgil Coblentz.

  • Coblentz, Virgil, 1862-1921
Date:
1896
Catalogue details

Licence: Public Domain Mark

Credit: The newer remedies. A reference manual for physicians, pharmacists & students / by Virgil Coblentz. Source: Wellcome Collection.

    47/100 (page 41)
    OUAIACOL BINIOBIDE. Is prepared by orecipitatin!? an aqueous solution of sodium Kuaiacol with a solution of iodine in potassium iodide. It forms a reddish- brown powder, possessinj? an odor of iodine, soluble in alcohol and tlie fatty oils. Nothing definite is known as to its dose. OUAIACOL CARBONATE, [C03(C8n40Cns)2]. Thedi-guaiacolester of carbonic acid, is formed by the action of phosgene gas on gualaool sodium. Tliis forms an in- odorous, neutral, crystalline powder, (containing 91.55( of guaiacol), insoluble in water, 'slightly so in alcohol, glycerin and the oils; melts at 6)° C. (149° B’.). The irritation produced by guaiacol, as well as creosote, has added to the popularity of this salt, which does not disturb the digestive functions, for, being insoluble, it nasses unchanged through the stomach into the intestines, where it is split up. The dose is C.3 to 0.5 Gm. (5 to 8 grains), gradually increasing to 5 Qm. (75 grains) daily. GUAIA COL CARBONIC A CID (CeHs (OH) (OCHa) COOH+SnaO. Is prepared by passing carbonic-acid over sodium-guaiacol heated to 100° C. (:112° P.), the resulting product on treatment with acids yields the free acid. This forms a white, crystalline, inodorous powder of bitter taste; slightly soluble in water, readily in alcohol and ether, melting at 150° C. (302° P.). Guaiacol carbonic acid and its alkali salts have been recom- mended as antiseptics and antirheumatics. This compound should not bo confused with Guaiacol Carbonate. OUAIACOL CnsnSFAMATE ov STYRACOL. C8n5.Cn=CII.C0aC6H4.0Cn3. Is the cinnamic ester of guaiacol. It is prepared by warming a mixture of guaiacol and cin- namyl chloride in molecular proportions. This compound forms colorless needles which melt at 130° C. (266° F.h insoluble in water, readily soluble in alcohol. Styracol is em- ployed in catarrhal affections of the digestive organs, also in the treatment of phthisis. GUAIACOL SALICYLATE or OUAIACOL-SALOL. CgG, (OH) COO-C«TT4- (OCIIs). A compound analogous to salol, is prepared by the action of phosphorus oxy- chloride on a mixture of guaiacol sodium and sodium salicylate. It forms a white, in- odorous, tasteless, crystalline powder, melting at 6.5° C. (149° P.), almost insoluble in water, soluble in alcohol and ether. It is administered to phthisical patients to aid digestion, also as an intestinal antiseptic in doses of 1 Gm. (15 grains). G UAIA COL PHOSPHA TE. PO (C«H4 O CHsOla. This salt is prepared by H. Du- bois by making a solution of guaiacol in soda lye, cooling, and then adding phosphorus oxychloride, drop by drop, in somewhat more than the theoretical quantity. After standing five or six hours an oily layer of the phosphate collects on the bottom of the vessel, which soon crystallizes, and is then purified by repeated washing with alcohol. It crystallizes in hard colorless tables, melting at 98°C. It is insoluble in water, alcohol and petroleum ether, and easily soluble in chloroform and acetone. GUAIA COL SUCCINA TE. This new ester of guaiacol may be prepared either by treating a mixture of guaiacol and succinic acid with a definite quantity of phosphorus oxychloride, or, preferably, by treating an aqueous soda solution of guaiacol. cooling it the while with succinyl chloride. It has the formula 0411404(0611400113)3. It crystal- lizes in fine needles with a silken luster, melting at 136° 0. It is Insoluble in water, slightly soluble in ether and alcohol, and readily so in chloroform. ,,.P^^,^^'^^^OSOTE. the oleic ester of creosote, prepared by combining creosote with oleic acid by means of phosphorus trichloride. This is a yellow oily liquid (35^ creosote), insoluble in water and nearly so in alcohol, soluble in ether and in oils It is used as an antiphthisic in doses of 15 to 16 minims. GUARANIN. See Caffeine. GYMNEMIC ACID. C3n560,3. The active principle prepared from the leaves of Gijmnema silvestre. It forms a greenish white powder, of an acid astringent taste, sparingly solub’e in water, easily in alcohol. It produces a temporary ageusia to sweet and bitter tastes. BefOTe partaking of bitter medicines, the mouth is rinsed out with a 12 per cent hvdro- alcoholic solution. ^ GYNOCARDIC ACID. The active principle from the oil of the seeds of Gynocarrlia odorata. It forms a yel owish, unctuous solid, melting at about 30° C. (86° P.); it has a burning and acrid taste, and marked odor. Used internally and externally in treatment of leprosy and bntaentwith^oim^^ affections. Dose, ^ to 3 grains; externally, as GYNOCYANAURIDZARIN. (®*’y-^talline) obtained from the Gymcardia lancifoliata. It forms un- in the usual solvents, soluble 1 in 5000 in olive oil, the solu- 1'a ®o by the addition of cinnamic alcohol. This solution grain) to the minim, is recommended in doses of 3 to 20 minims in various forms of tubercular affections.