Experimental rickets : the effect of cereals and their interaction with other factors of diet and environment in producing rickets / by Edward Mellanby.

Edward Mellanby

Date:: 1925

Credit: Experimental rickets : the effect of cereals and their interaction with other factors of diet and environment in producing rickets / by Edward Mellanby. Source: Wellcome Collection.

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$(iiij Green Vegetables. I had1 5w!“ a fuU Tirt °f thiS investigation was published, , , noti. been. successful in carrying out experiments to test die anti-rachitic action of green vegetables on puppies In view of the experimental work which had previous^ demon obSuslv d Pre8?“cet,0fi Vitrin A in these ^stances, !“ obviously desirable that information as to their anti-rachitic properties should also be obtained, more especially because one of the main features of my work up to that point had been to compare of S£8SrttiC the gro^h-promoting properties neient tooclstufts. It may be remembered that although the properties and distribution of the anti-rachitic substance and vftamin A weie very similar, there were some differences which it appeared mpossible to explain at the time. This subject has since formed thatb whp0t “if7 0tI16r “vestigations> a staking observation beino- as teste bv® iV,ltamin A-COntent 0f greei1 vegetables (spinach) rat is b 7 f Prom°tMn ot and cure of ophthalmia in Shuck heif antl:rach!t,c effeet is absent. McClendon and cmcd onhthbLT, rr’lbUndithat.0-1 t0 0-5 Sms- of d™d spinach when fPhthaimia hut did not protect against rickets in rats, even found tbit™16*1! .P?' Centi °f ,the diet tucker and Barnett [6] also round that an alcoholic and ether extract of spinach did not protect X™ “d A rfS; but.Promoted their growth when the diet was otherwise devoid of vitamin A. Similar results were obtained with so Ivelhifr Gmdbla-t and ZlIv? W Mueh of the work designed to in th! Problem is open to the criticism that the basal diets used a-a? L §i0wth experiments and in the rickets experiments are inf tliTt “Pff.f'tbe. fft-soluble vitamin factor, and it seems to and™ T f * let. baSal d\ets are the same in both types of work their fa Pi®, l f° far as ls known, m all respects except as regards n,.!i i fat-soluble vitamin content, no satisfactory solution of this problem can be reached. The following experiments were carried out on puppies to test food stuff k d a ?a °J Cabbage- “ wil1 be seen that this foodstuff has a definite effect m this direction. When oatmeal is the ceieal eaten and the diet is otherwise deficient in anti-rachitic tamin the influence of cabbage is small, but when bread replaces oatmeal the improvement in bone-formation is more obvious. The Antagonistic Effect of Cabbage to the Rickets-producing I nfluence of Cereals. u Age at beginning of experiment: 10 weeks. -Diet eaten daily by both puppies included separated milk powder 20 to 25 gms., meat 20 gins., yeast 5 gms., orange juice ° 1Ve °d 10 c-cms-’ sodlum chloride 2-3 gms., and oatmeal ou-loO gms. In addition 616 received cabbage 20-130 gms. daily. This was c lopped up finely and boiled in water for 20 minutes before being ac rrr t0 C^e^‘ cakkage water was added to the diet. he control diet eaten by 613 is potently rickets-producing, as$