The nature of the cancerous processes and the cancerous cachexia, and the relation of local irritation to each / by Roswell Park.

  • Roswell Park
Date:
[1900?]
Catalogue details

Licence: In copyright

Credit: The nature of the cancerous processes and the cancerous cachexia, and the relation of local irritation to each / by Roswell Park. Source: Wellcome Collection.

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    cancer from one part to another of the human body, by the surgeon, might also be added, such as the case re¬ ported by Claude and Pilliet, where this result followed an autoplastic operation (Bull. de la Soc. Anat.} 1895)- As illustrating the defects of labora¬ tory research in this direction, a very abbreviated list of those who have made various injection experiments and failed to secure positive results would begin at least with Peyrilhe, who, about 1772, injected cancerous juice into the veins of dogs, and thus instituted a series of experiments con¬ tinued and modified by such eminent pathologists and surgeons as Dupuy- tren, Weber, Doutrelepont, Billroth, Lebert, Villemin, Tilanus, Klebs, Israel and many others. A list of failures by such eminent authorities proves not necessarily the impossi¬ bility of that which they were trying to accomplish, but rather the inutility of the methods adopted by them, as well as the extreme difficulty attend¬ ing this line of investigation. Other observers, and for the most part much more recent, have obtained varying or questionable success, as for in¬ stance, Firket (Semaine med., 1893), who thus produced sarcomata in a rat which killed the animal in five weeks, or Pfeiffer {Die protozoeii als Krarik- heitserreger, 1891), who reproduced melanotic cancer from a primary cancer of the limb of a young girl, or Mayet (Comptes rendus, 1893), who used a glycerine extract of a mammary tumor and produced can¬ cerous nodules in the kidneys of a rat, or Boinet (Marseille med., 1894), who had about the same result. Much more successful, and only so as we appreciate conditions, are those experiments where malignant tumors have been transmitted from one ani¬ mal to another of the same species A number of observers have succeede in efforts of this kind. A growth of epithelioma upon lupus has been noted by numerous observ ers, and has been particularly studied in literature by Raymond (An?i. de dermat. el syph., 1887), and Desbon- nets ( Devel. de /’ epithel. sur le lupus, These de Paris, 1894). This compli ■ cation is never observed with lupus erythematosus but only after a true tubercular form, whether of the florid or the ulcerating type, or even .after complete cicatrization. Of 90 cases collected by Desbonnets 21 concerned lupus scars, and in all the other cases the lesions were old before the epithe¬ lioma began to grow. It is difficult to fix the degree of frequency of this particular complication. Feloir ( Traite de la Scrofulo-tuberculose) put it at 15 to the 1000, while Dubois- Plavenith ( These de Bruxelles, 1890) oberved it five times in 118 cases of * lupus. In other cases also of tubercular primary lesions besides those of the skin which we call lupus, cancerou alterations may be met as later sequences or, as I would call them, secondary infections. Or they may more rarely appear almost coinci- dently. Syphilitic lesions or their resulting scars may equally be points of depart¬ ure for these cancers, either on mucous surfaces or in the viscera. They have been observed often in the mouth upon the penis, the skin, the vulv£ and the testicle. Fistulous tracts again, especially those leading inward from the skin, with a gradual downward extensio 1 n 'igi 1?C; k ■DOS' bsf It 4i it lei jro
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