Licence: Public Domain Mark
Credit: On mycetoma, or, The fungus disease of India / by H. Vandyke Carter. Source: Wellcome Collection.
Provider: This material has been provided by the Royal College of Physicians of Edinburgh. The original may be consulted at the Royal College of Physicians of Edinburgh.
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![Illustrations of the minute structure of tlie fungus-particles [ALi/dco/ia), beloilging to the pale [OcJirohl] variety of Mycetom'a. Fig. 1.—TLe true fimgus-elements found in the case of the woman described at page 8; for description see page 73. a. Natural size of the particles. h. Particles as seen magnified by aid of a lens ; their normal colour, and their tuberculated exterior are here shown. c. An entire smaller particle, as seen with |-inch objective. Its true cellular character is apparent. d. Free surface of the same, as seen under a higher power (x 250 diameters). The luxuriant growth and multiplication of the component cells is clearly seen; no other structures but these exist. Some of the beaded filaments have a dilated extremity, but sporangia had not formed; nor were conidia seen to be detached. At the lower part of the circle is shown the structure of the filameuts described in the text, at page 73, as being present in the gelatinous matrix holding the fungus-particles, in the foot. The relation of these filaments to the particles was not made out. e. Contents of the fluid discharged from openings in the foot. Besides pus-cells, blood-corpuscles, and granirle- masses, there were seen the small collections of fungus-growth shown in the figure. Sometimes the beaded fibres were large and distinct; at others, smaller filaments were seen, shown to the right and below. X 300 diameters. /. One of some particles, occasionally detected. They were opaque in parts corresponding to the nucleus or centre, and to certain rays passing otf in a radiating manner. It seemed to me that the dark globular centre corre- sponded to the body of an ovAimxy malacoiinm; whilst the incipient rays would form its crystalline envelope; and that there was here a transition from these distinctly cellular bodies, to the more obscure ones, which are commonly found. Fig. 2.—The pink particles found in the specimen from Madura, ^ee page 9. a. Natural size and appearance of the particles. h h. Particles as seen with a power of 200 diameters. Their varying size, form, and construction are here shown. For description, see page 74. c. A particle of different colour. It had burst open in the manner shown ; and the finely-granular interior was then seen ; the same appearance was present in other specimens. d. Globules of oil, of varying sizes ; they partake of the pink hue, and give rise to the general tint. e. Collections of fat-crystals. /. A globe epidermique found amongst the pink particles ; there Avere, besides, several masses of epithelial scales, of great delicacy. Fig. 3.—Fungus-particles (malacotia) of the kind commonly met with. For full descriptions, see page 74. a. Natural size and appeai'a.nce of these bodies. b. A small collection of them, still in apposition, and retaining part of their crystalline fringe. The larger, compact aggregations, which have been compared to the 'ova of fishes,' to 'poppy-seeds,' &c., have a similar general arrangement of the particles and fringes. Taken from a perfectly fresh specimen just removed from the foot. X 200 diameters. c. An ideal particle, but founded on fact. In the centre is the essential element—the malacotium—of globular form and tinted hue; and surrounding it, on all sides, is the crystalline envelope, which is regarded as being composed of the more solid fat-principles. At * is one of these fatty corpuscles of a complicated character. d. One of the particles taken from the Bhooj specimen, described at page 9, and here represented as showing certain peculiarities. The interior of the compressed mass is seen to contain several ovoid bodies, which had a certain resemblance to spores, or secondary cells, but which were, probably, globules of oil; and the crystalline envelope was here of more complicated consti-uction than usual. X 250 diameters. See page 76. e. The appearance of a ' malacotium,' as viewed with a power of 700 diameters. The specimen had been preserved in dilute alcohol. /. A portion of the same, more highly magnified. Fig. 4.—Structure of the membrane investing the black particles and lining the canals; as seen in the specimen from Bhooj, described at page 4. There ai'e—1, a fibrillated structure; 2, myriads of cells or nuclei; 3, tubes filled with cells or nuclei; but these latter are not shown in the original figure. Fig. 5.—Structures found adherent to, or imbedded in the above membrane, It would seem as if the growth of a mycelium had commenced in this instance; see page 70. X 200 diameters. Fig. 6.—The structure and arrangement of the ' pink stains,' which are supposed to indicate an incipient stage of growth of the fungus-particles. See page 78. a. From the skin of the said specimen (melanoid variety, Case 3, page 4). The appearance is as if some natural tubes or ducts had become filled with coloured granules ; an isolated, spheroidal group is seen, the individual particles forming which had a diameter of ^TgVo — 6 oVo i^- b. Other pink stains in the skin. Collections of coloured granules are seen, which are probably ' zooglasa-forms' appei'taining to the early stage of the parasitic growth. c. From the same foot. Here are various structures, described in the text, which seem to indicate stages in the development of the fungus-particles. Fig. 7.—Other like stractures from a specimen of the Ochroid vai'iety of Mycetoma; that, namely, from Bhooj. See page 80. a. Bodies found free, in a section made near the toes. b. Another ' zoogloea-mass ' from the same part. c. A still larger similar collection. Fig. 8.—Bodies seen in the substance of the skin, in a perfectly fresh specimen of the pale variety of Mycetoma, (Case 4, page 10) + acetic acid + glycerine. Some of them were seen in close contact with the sweat-ducts, but not, to all appearance, within them. They were arranged in streaks, not unlike those seen elsewhere. Fig. 9.—Bodies taken fi-om the same specimen; they were found alongside a tendon, in its sheath. Fig. 10.—Structures seen near the aperture of a canal (Bhooj specimen, second variety). They seem to indicate the mode of origin of the soft, pale particles; commencing at the right hand and proceeding towards the left, the gradual transition of forms may be seen, which intervene between bodies like those found in the skin, and the mature malacotium.](https://iiif.wellcomecollection.org/image/b21951809_0190.jp2/full/800%2C/0/default.jpg)
