Blood : a study in general physiology / by Lawrence J. Henderson.

  • Lawrence Joseph Henderson
Date:
1928
Catalogue details

Licence: In copyright

Credit: Blood : a study in general physiology / by Lawrence J. Henderson. Source: Wellcome Collection.

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    increased.103 But no evidence exists to show that more than these eight variables need now he considered. We have also seen that total oxygen, hydrogen ion con¬ centration, volume of cells, the Donnan r, and the other variables which have thus far engaged our attention are all functions of total carbonic acid. Therefore they too are functions of the eight independent variables. In all these cases, also, there is no evidence that other independent variables need to be considered. The comparative study of blood has not yet made great progress, and the explicit forms of all of these equations in eight independent variables remain unknown. In gen¬ eral, existing knowledge of the facts has been acquired by the study of blood which has been removed from the body and in which the masses of the components H20, HC1, BOHs, and BOHc, Ps and Pc are all constant, though varying from specimen to specimen, while only pC02 and p02 remain as independent variables. If temperature also is held constant, we have, in contrast with the case of mammalian blood in general, for each specimen of blood relatively simple equations of the type Total C02 = f1 (pC02, p02), (3) Total 02 = /2 (pC02, p02). (4) And these two equations are, in fact, the analytical ex¬ pression of the discoveries of Bohr, Hasselbalch, and Krogh104 and of Christiansen, Douglas, and Haldane.105 The case of the acid-base equilibrium is not different from those of the absorption of oxygen and of carbon di¬ oxide. Here we have (equation 6, page 42). [H+] S c • pC02 [BHCOs] s 103 The experience of Van Slyke’s laboratory shows that differences in the hemoglobins of different mammalian species are small but meas¬ urable. 104 Bohr, Hasselbalch, and Krogh, Skandinavisches Archiv fur Physiologic, XVI, 411 (1904). 105 Christiansen, Douglas, and Haldane, Journal of Physiology, XLVIII, 244 (1914).
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