Blood : a study in general physiology / by Lawrence J. Henderson.

  • Lawrence Joseph Henderson
Date:
1928
Catalogue details

Licence: In copyright

Credit: Blood : a study in general physiology / by Lawrence J. Henderson. Source: Wellcome Collection.

    94/434 page 68
    librium between base, serum proteins, and carbonic acid. Let there be present in a solution approximately that amount of base which is ordinarily distributed between carbonic acid and serum proteins in normal blood, say 30 millimoles per liter, let the serum proteins amount to 50 grams per liter, and let the pressure of carbon dioxide be variable. The temperature is 37°. Then from the facts above discussed we may deduce the values of table 2. The two last rows of table 2 include the data necessary for the construction of a carbon dioxide dissociation curve of the system. TABLE 2. pH . 6.61 6.83 7.12 7.42 7.61 7.83 8.12 [BP] . 6.1 6.9 7.9 8.9 9.6 10.25 10.7 [BHCOJ . 23.9 23.1 22.1 21.1 20.4 19.75 19.3 R= Jj^J3 .. 1:3 1:5 1:10 1:20 1:30 1:50 1:100 [BHCOs j [H2C03] . 7.97 4.62 2.21 1.05 0.68 0.395 0.193 Total C02 . 31.9 27.7 24.3 22.2 21.1 20.2 19.5 Next we may take the case of hemoglobin, carbonic acid, and base. We now choose the concentration of total base as 43 millimoles per liter, a fair value for the sum of the base distributed between hemoglobin and carbonic acid in normal arterial blood, the concentration of hemoglo¬ bin as 147 grams per liter. The other conditions are un¬ modified. Calculation gives table 3. It will be seen that table 3 must yield a dissociation curve of quite a different character from that of table 2. TABLE 3. pH . 7.12 7.24 7.42 7.61 7.83 7.95 [BP] . 7.8 13.0 20.5 28.2 36.2 42.6 [BHCOJ . 35.2 30.0 22.5 14.8 6.8 0.4 TH CO 1 R=ri * »J .... 1:10 3:40 1:20 1:30 1:50 1:67 [BHCOg] [H2COs] . 3.52 2.24 1.125 0.493 0.136 0.006 Total C02 . 38.7 32.2 23.6 15.3 6.9 0.4
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