Some aspects of lymphadenoma (Hodgkin's Disease) / by H.D. Rolleston.

  • Humphry Rolleston
Date:
[1911?]
Catalogue details

Licence: In copyright

Credit: Some aspects of lymphadenoma (Hodgkin's Disease) / by H.D. Rolleston. Source: Wellcome Collection.

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    it in the armpit after an infected wound of the finger. In an acute case with considerable implication of the liver and spleen recorded by Parkes Weber10 there was a duodenal ulcer. It is three times commoner in males than in females ; most of the cases begin in early adult life. The cause is unknown. Bacteriological investigation has not shown any constant infection. The results in some cases have been positive and several organisms—for example, pyogenic micrococci and B. proteus (Longcope)—have been described, but were probably due to intercurrent or terminal infection. Dreschfeld,11 in 1892, described a small bacillus; Delbet,12 in 1895, cultivated a bacillus, and by giving large injections of the culture to a dog he produced glandular enlargements from which he isolated the bacillus in pure culture. These results have not been confirmed. In 1909 Byrom Bramwell13 mentioned that in two of his cases pro¬ tozoan organisms resembling minute bacilli had been found by Ford Robertson and Young. Quite recently Fraenkel and Much have described a bacillus morphologically identical with the granular form of the tubercle bacillus, but not acid- fast. They have not been able to cultivate it. White and Proescher,14 using the Levaditi method, described a spirochaste in lymphadenoma and regarded the disease as a spirillosis. Their observation, which has not been confirmed, though McDonald, Turnbull, and others have attempted to do so, is attractive for the following reasons :—(a) The frequency with which an increase in the number of eosinophil cells occurs in the lymphadenomatous glands ; this was first noticed by Goldmann15 in 1892 and is now fully recognised. As is well known, eosinophilia is characteristic of infection by animal parasites. (b) The occasional occurrence of eosinophilia in the blood; though, as a rule, there is no eosinophilia, it may be very remarkable, as in Lincoln’s case of acute lymph- adenoma in which there was 68 per cent, of eosinophils.16 10 Weber, Parkes: St. Barth. Hosp. Rep., Lond., 1907, XLIII., 81. 11 Dreschfeld : Brit. Med. Journ., 1892, I., 892. )? Delbet: Semaine vied., Par., 1895, XV., 271. 18 Bramwell: “Clinical Studies,” Edm., 1909, VIII., 131. 14 White and Proescher : New York Med. Journ., 1908, LXXXVII., 9. 19 Goldmann : Centralbl. f. allg. Path. u. path. Anat., Jena, 1892, III., 668. ,K Lincoln : Medical Papers dedicated to R. H. Fitz, 1908, p. 273 ; Boston Med. and Sing. Journ., 1908, CLVI1I.