Round celled sarcoma of the anterior mediastinum : extensive metastases, including the brain, both choroid coats, oculo-motor and optic nerves, and external ocular muscles / by Arthur V. Meigs and G. E. de Schweinitz.

  • Arthur V. Meigs
Date:
[1894]
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Licence: Public Domain Mark

Credit: Round celled sarcoma of the anterior mediastinum : extensive metastases, including the brain, both choroid coats, oculo-motor and optic nerves, and external ocular muscles / by Arthur V. Meigs and G. E. de Schweinitz. Source: Wellcome Collection.

Provider: This material has been provided by UCL Library Services. The original may be consulted at UCL (University College London)

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    Ophthalmoscopic examination was impossible, owing to opaci- ties in the media, but the microscope showed that the secondary growth had originated from the optic papilla. Hence the case is not properly classed with choroidal growths. In the case forming the basis of this paper, unfortunately ophthalmoscopic examination is wanting, but the anatomical studies are sufficiently detailed to demonstrate secondary choroidal sarcoma. It is scarcely conceivable that the cho- roidal srrowth under these circumstances could have been the primary one, although, as is well known in a few instances, extremely small and totally unsuspected growths in this situa- tion have been followed by very extensive metastasis; in one case quoted by Fuchs, a melanotic mass was found in the heart secondary to a small sarcoma in a shrunken eyeball, which had existed in this condition for more than twenty years. Independently of the fact that the sarcomatous deposits in the eye were confined within the scleral walls, and were both clinically and microscopically of the nature of secondary growths, the mediastinum rarely suffers from this form of tumor, save as a primary growth. Among ninety-eight cases reported by various authors and collected by H. A. Hare,^ but five were secondary and thirty-one were primary, the remain- ing number having no distinct reference in regard to this point. The interesting fact has been noted that so far as the optic nerves, third nerves, and orbital contents are concerned, the microscopic evidence is that the disease travelled from the brain forward toward the eyes along these pathways, but the localized character of the choroidal neoplasms and their failure to be in any demonstrable connection with other sarcomatous areas, seems definitely to indicate that they should be regarded as embolic deposits. 1 The Pathology, Clinical History, and Diagnosis of Affections of the Mediastinum Fothergillian Prize Essay. Philadelphia, 1889.
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