The release of histamine / by W.D.M. Paton.

  • William Paton
Date:
1958
Catalogue details

Licence: In copyright

Credit: The release of histamine / by W.D.M. Paton. Source: Wellcome Collection.

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    Table III Histamine Depletion in the Cat Tissue Histamine /tg/gm % Histamine depletion Skin: ear. Normal 96 48/80 treated 12 87 abdomen. 22 5 77 Skeletal muscle: diaphragm.. 2.6 1.9 27 gastrocnemius .... 2.1 1.5 29 Stomach: corpus mucosa. 29 20 31 sub-mucosa. 19 12 37 Muscularis externa 12 11 8 Stomach: pyloric region mucosa. 23 23 0 sub-mucosa. 17 18 — 6 Muscularis externa 10 10 0 Duodenum. 40 35 12 Ileum . 22 19 14 Colon . 11 11 0 Liver.. 2.9 2.7 7 Pancreas. 3.3 2.5 24 Spleen. 8.1 9 —11 Lung. 35 22 37 Kidney. 1.2 1.5 —25 (From Smith, 1953) rise. It was interesting that the response to histamine infusions also changed and a distinct pressor response, abolished by adrenalec¬ tomy was found. Smith also found that the gastric secretion produced by injection of 48/80 diminished in treated animals. Brocklehurst, Humphrey and Perry (1955) in work on the allergic responses obtainable in the rat and guinea-pig, point out that even the most stringent measure for reducing the histamine content of rat’s skin will not bring it much below about 3 /ig./gm. This was true even though 48/80 was combined with octylamine, with hyaluronidase, with the induction of an allergic reaction, or with all these procedures together. They also noted that in the guinea-pig, whose skin histamine content is a good deal lower than of the rat, the proportionate reduction of histamine content produced by 48/80 is also much smaller. They suggest from this that there may be in all species a fraction of skin histamine, perhaps 3 jug./gm. magnitude, which is insusceptible to mobilization by chemical releasing agents. This does not square with Feldberg and Patou’s
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