The release of histamine / by W.D.M. Paton.

  • William Paton
Date:
1958
Catalogue details

Licence: In copyright

Credit: The release of histamine / by W.D.M. Paton. Source: Wellcome Collection.

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    outwards to fulfill some function in the connective tissue. Further, the mast cell population differs in its response to histamine releasing agents (Fig. 3). Thus if a rat is treated with Compound 48/80, the proportion of mast cells which become degranulated increases as the dose of the drug is increased, implying that the cells differ in Fig. 3a. “Acute dosage” experiment. Mesentery 3 hours after intraperitoneal injection of compound 48/80, showing shattered mast cells swelling and increased basophilia of the adventitial cells. Very little histamine remained in this tissue. Toluidine blue. X 580. (From Riley and West, 1955). - Fig. 3b. “Subacute dosage” experiment. Subcutaneous connective tissue on third day of intraperitoneal injection of the histamine-liberator. One exceptionally large mast cell near the top remains unaffected. The remaining mast cells, in a slightly different tissue plane, all show varying stages of swelling and degranu- lation-“ghost” cells. This is a reversible process. Toluidine blue. X 350. (From Riley and West, 1955.)
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