Volume 1

The internal secretions and the principles of medicine / by Charles E. de M. Sajous.

  • Charles E. de M. Sajous
Date:
1912
Catalogue details

Licence: In copyright

Credit: The internal secretions and the principles of medicine / by Charles E. de M. Sajous. Source: Wellcome Collection.

    26/882
    And, in \nrtue of the four last conclusions:— 76. The manner in which sleep is provoked; 77. That anajsthetics of which chloroform and etlier are types, produce sleep and ana;sthesia by e.xciting powerfully the vasomotor cen- ter, causing thereby general vasoconstriction followed by hypenemia of all capillaries, including those of the ccrebro-spinal system, and ven- osity of their arterial blood; 78. That anajsthetics of which nitrous o.vide is a type, produce sleep and aniesthe.sia by replacing the o.xygen of the air and producing venosity of the blood in the capillaries of the cerebro-spinal system and other organs; 79. That ])ain is due to hyperaimia of the sensory-nerve terminals, of the nervi nervorum, etc., and that any agent which indirectly or directly causes diminution of this hyperaimia counteracts pain; An.d, in virtue of this conclusion:— 80. The nature and mode of production of pain; 81. That analgesics of the type of opium counteract pain by stim- ulating the sympathetic center, and by thus causing the dilated arte- rioles which supply the painful area to resume their normal caliber; 82. That analgesics of the type of antipyrin, acetanilid, etc., counteract pain in the same way, but, being more violent in their action, are apt to cause hyperconstriction of the arterioles and cyanosis; 8;i. That drugs of the type of amyl nitrite, nitroglycerin, etc., produce dilation of the arterioles by inhibiting the functional activity of the sympathetic center; 84. That drugs of the type of veratrum viride, the bromides, etc., lower the vascular pressure by inhibiting the functional activity of tho vasomotor center; 85. That alcohol is a fictitious stimulant and in reality a depres- sant, owing to the fact that it deo.\idizes the plasmatic adreno.xidase; 86. That the mineral salts fulfill so important a role in the pre- servation of the osmotic properties of the body fluids and their alka- linity, that their replacement in all diseases in which they are actively reduced is an essential feature of the curative procecs; 87. That purgatives produce their beneficial elTects by causing either rellexly or by centric action, according to the purgative u.sed, an increase of bacteriolytic and antito.xie auto-antitoxin in the intestinal canal; 88. That all emetics produce their elTccts by provoking irritation of the giistric mucosa: the local emetics (mustard, zinc sulphate, etc.) by irritating it directly; the general emetics (apomorphine, tartar emetic, etc.) by depressing markedly the vasomotor and sympathetic centers and thus cau.sing dilation of the arterioles and hyperajmia of the gastric glandular elements; 89. That dia])horetics act similarly, the sweat glands (as well as all other glands) being rendered hj'pera;mic and overactive. Bearing directly upon Pathogenesis and Therapeutics:— 90. That the vulnerability of the organism to infection is inversely proportional to the efficiency of the adrenal system, the relative amount of auto-antitoxin in the pulmonary and intestinal secretions, and tho bacteriolj'tie activity of the phagocytes; 91. That the diseases which are most fatal to mankind: cancer, tuberculosis, pneumonia, Asiatic cholera, bubonic plagiie, etc., are due to agencies, endogenous or exogenous, which interfere with, or paralyze, the functions of tho test-organ and through it the adrenal system; 92. Tliat all these diseases can be treated successfully, when s(wn not too late, by means of remedies which excite with adequate activity