Hæmatoporphyminuria and its relations to the source of urobilin / by David Fraser Harris.

  • David Fraser Fraser-Harris
Date:
[1898]
Catalogue details

Licence: Public Domain Mark

Credit: Hæmatoporphyminuria and its relations to the source of urobilin / by David Fraser Harris. Source: Wellcome Collection.

Provider: This material has been provided by The University of Glasgow Library. The original may be consulted at The University of Glasgow Library.

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    a place to it by regarding it as less de-oxidised than uro-hfemato- porphyrin: the series of bodies in descending scale of possession of oxygen would therefore be—haematin, hsematoporphyrin, meio-de-oxy-haematoporphyrin, uro-hsematoporphyrin, Patholo- gical Urobilin. [M'Munn actually made uro-haematoporphyrin by reducing hsernatin with zinc and sulphuric acid, and further reduction yielded a pigment identical with Pathological Urobilin; but he failed to produce it from bilirubin.] If one makes a survey of the diseases in which uro-haemato- porphyrin has been recognised, it is noticed that they all present lesions of one or other of the systems (1), (2), or (3), as given above. Thus, those involving the muscular system or connective tissue, or most probably both at once, are acute rheumatism, pericarditis, meningitis, peritonitis, and cirrhosis of liver. Three are the acutely febrile, croupous pneumonia, typhoid, and measles,—the last two with cutaneous involvement; also Addison's disease and Hodgkin's disease,—both disorders of pigmentary metabolism, and involving a cutaneous factor. [Haematoporphyrinuria has also been described by Oswald1 in sulphonal over-dosing in the insane, and Stokvis produced it by feeding rabbits with sulphonal.2] Lastly, of three cases of meio- de-oxy-haematoporphyrin, two of them are obscure, being in neurotic women, but one was a case of profound cutaneous lesion (Professor M'Call Anderson's). Briefly, then, we may say, that in health pigmentary meta- bolism in the three great systems already alluded to forms from haematin the urobilin-chromogen, that this on traversing the lungs is oxidised to urobilin, which on traversing the kidneys is partly de-oxidised to the chromogen, partly excreted as urobilin. It is probable that even in health a certain quantity of Patho- logical Urobilin is formed by these three systems, but is partly de-oxidised to its chromogen at renal elimination. M'Munn has, however, seen 'Pathological Urobilin' in stale normal urine. That on being passed the bands of Pathological Urobilin are not seen, is perfectly explicable on the supposition that it is, like urobilin, present in too small quantity to give a spectrum, 1 Glasgow Medical Journal, January 1895. 2 Cenlralblatl fur physiol., 25th July 1S96.
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