Dictionary of the active principles of plants: alkaloids : bitter principles; glucosides; their sources, nature, and chemical characteristics / with tabular summary, classification of reactions, and full botanical and general indexes. By Charles E. Sohn.
- Sohn, Charles E.
- Date:
- 1894
Licence: Public Domain Mark
Credit: Dictionary of the active principles of plants: alkaloids : bitter principles; glucosides; their sources, nature, and chemical characteristics / with tabular summary, classification of reactions, and full botanical and general indexes. By Charles E. Sohn. Source: Wellcome Collection.
Provider: This material has been provided by The University of Leeds Library. The original may be consulted at The University of Leeds Library.
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![Precipitated by alkaline hydrates and ammonia, flocculent pp. becoming crystalline. (4d) APOCINCHONICINE A. Produced from preceding alkaloid by heat- ing in sulphuric acid to 130°-140°. Optically inactive ; unstable. Soluble in alcohol, e'her, chloroform, and dilute acids. • Precipitated by sodium hydrate ; resinous. (4e) DIAPOCINCHONINE A., Ci8H44N402. Formed during preparation of Apocinchonine. Pale yellow, amorphous, dextro-rotatory (about -f- 20° in 97 per cent, alcohol). Soluble in alcohol, ether, and chloroform. Precipitated by alkaline hydrates (pp. resinous) and ammonia. (4/) HYDROCINCHONINE A., C19H24N20. Occurs naturally, also pro- ducible from Cinchonine by reduction. Usually amorphous (as are the salts). Alkaline reaction ; M.P. 256°. Soluble in alcohol and ether. (4,7) CINCHOLEUPONIC ACID, C8H1:jN04+H,0. Formed with other sub- stances from Cinchonine by action ot chromic tind dilute sulphuric acids. [E. Jungfleisch (Compt. Ixend., 105 and 105), to whom are also due the next six substances, 4/t to 4m, which were prepared by heating cinchonine with sulphuric acid for five days.] (4A) CINCHONIBINE, A., C19H22TnoO. From cinchonine ; see 4g. Prismatic needles; alkaline reaction; dextro-rotatory (175-8° in alcohol); M.P. 259° ; yielding sublimate. Soluble in hot alcohol, not in ether or water. Precipitated by alkalies. (40 CINCHONIFINE A., C19H22N20. From Cinchonine ; see 4g. Crystal- lizes in needles from alcohol; dextro-rotatory (195° in alcoholic solution). Soluble in alcohol, but not in ether. (4/) CINCHONIGINE A., C19H22N20 (regarded by O. Hesse as identical with Isocinchonine, 4a, or amorphous Cinchonine). From Cinchonine ; see 4//. Crystallizes in prisms; M.P. 128°; distils under reduced pres- sure ; lasvo-rotatory ( — 60-l° ; 1 per cent, solution in alcohol) ; alkaline reaction, non-fluorescent. Soluble in ethyl, methyl, and amyl alcohols very readily; also in ether, benzene, chloroform, and acetone ; slightly in water. Precipitated by alkalies. (4A) CINCH0NILINE A., C^H^O. From Cinchonine ; see 4g. Readily crystallizes in rhomboidal prisms ; M.P. 130-4° ; distils in vacuo ; dextro- rotatory (+532°; 1 per cent, solution in alcohol) : strongly alkaline. Soluble easily in alcohol, ether, chloroform, benzene ; also soluble in methyl alcohol and acetone ; slightly in water. Precipitated by alkalies. Reduces alkaline permanganate. (4/) ALPHA-0XY-C1NCH0NINE A, C19H„aN,0., From Cinchonine ; ?ee 4g. Crys. prisms and needles ; dextro-rotatory (+182-56°); Soluble in dilute alcohol, not in ether. Precipitated by alkalies. (4m) BETA-0XY-CINCHONINE A., C19H22N202. Formed with above. Crys. needles; dextro-rotatory (4- 187'14°). Soluble in dilute alcohol, not in ether or acetone. (4n) CINCH0NICINE A., C19H2;NoO. See Quinoidine (24). Light yellow, amorphous, gummy (so-called crystallized Cinchonicine = Cincho- nine, O. Hesse) ; M.P. about 50° ; alkaline, bitter. Soluble in alcohol, ether, chloroform, benzene, and acetone. Reactions : very much like those of Quinicine. Sodium hydrate : cloud and gradual pp. Ammonia : partial precipitation. (Does not give thalleioquin reaction with chlorine water, etc.) (4o) CARTHAGINE. Probably a mixture of Cinchonine and Cinchonidine (Hesse, Aiinalen, 166, 251) ; see also 5. (4p) CINCH0TINE A. (not Hlasiwetz's Cinchotine, which is Quinidine), C19H24N„0. Accompanies Cinchonine; found also in Remijia bark. Crys. prisms and leaflets ; M.P. 268°-277° (Skraup) ; dextro-rotatory. Soluble in alcohol, in 534 parts of ether and 1,360 of water. (4q) DICINCH0NINE A., C40H4(iN4O:i. Accompanies Cinchonine and Quinine in most Cinchona barks (Hesse). Amorphous, alkaline, dextro- rotatory, fluorescent. Soluble in alcohol, ether, chloroform, benzene, acetone. Insoluble in water or petroleum ether ; pp. tartrate. Gives the thalleioquin reaction. (5) QUINIDINE A. (Hesse's Conquinine : van Heiningen's lieta-quinine ; Hlasiwetz's Cinchotine ; Gruner's Carthagine ; Mnratory's Pitayine ; Lowig's Quinotine), Co()H24N20o+2^H20 (from alcohol) ; crys. four- sided prisms or needles ; also hydrates with lh and 2 H20. Feebly alkaline, bitter, dextro-rotatory (236-7°-3-01 C, Hesse) ; M.P. 120°](https://iiif.wellcomecollection.org/image/b21503023_0045.jp2/full/800%2C/0/default.jpg)
