Formulary for the preparation and mode of employing several new remedies : namely, morphine, iodine, quinine ... / with an introduction, and copious notes, by the late Charles Thomas Haden ; translated from the French of the third edition of Magendie's "Formulaire."
- François Magendie
- Date:
- 1824
Licence: Public Domain Mark
Credit: Formulary for the preparation and mode of employing several new remedies : namely, morphine, iodine, quinine ... / with an introduction, and copious notes, by the late Charles Thomas Haden ; translated from the French of the third edition of Magendie's "Formulaire.". Source: Wellcome Collection.
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![ACTION OF PICROTOXINE ON THE ANIMAL ECONOMY. Ten grains (gr. 8.20 troy) of picrotoxine, in¬ corporated with crumb of bread, were given to a young middle-sized dog. At the end of twenty-five minutes, convulsions occurred, and, subsequently, staggering, which continued for the space of a quarter of an hour. The animai fell upon his side, experienced violent convul¬ sive motions, and death took place at the end of forty-five minutes. On dissection, the sto¬ mach, filled with aliment, exhibited very marked signs of inflammation, for about an inch in extent, around the cardiac orifice; the mu¬ cous membrane was red, but without any softening. A similar dose of the crystallized acetate of picrotoxine, well dried, exhibited in the same manner to a dog of nearly equal strength, occasioned some indisposition and tremor; but at the expiration of three hours the animal did not appear to suffer any incon¬ venience0. M. Orfila affirms that picrotoxine acts upon the animal economy like camphor, but much more actively. c [Journal de Pharmacie. Janvier, 1819,] G 2 J](https://iiif.wellcomecollection.org/image/b30796568_0149.jp2/full/800%2C/0/default.jpg)
