Supplement to a textbook of pharmacology, therapeutics and materia medica.

  • Lauder Brunton
Date:
1891
Catalogue details

Licence: Public Domain Mark

Credit: Supplement to a textbook of pharmacology, therapeutics and materia medica. Source: Wellcome Collection.

Provider: This material has been provided by Royal College of Physicians, London. The original may be consulted at Royal College of Physicians, London.

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    This incompatibility is important, as antipyrine is not unlikely to be given along with nitrous ether, quinine, or bark in febrile conditions or neuralgia, or with nitrite of amyl in angina pectoris. G-lusidum. Gluside. Commonly known as ‘ Saccharin.’ Synonyms. —Glucusimide ; Benzoyl-sulphonic-imide, C6H4CO'SO,*NH. A sweet imide derivable from the toluene of coal-tar. Characters and Tests.—A light, white, minutely crystalline powder, hav- ing an intensely sweet taste in dilute solutions. It is but slightly soluble in cold water or chloroform, more so in boiling water, rectified spirit, or glycerine. It is very soluble in diluted solution of ammonia; also in solution of bicar- bonate of sodium with evolution of carbonic acid gas. The latter solution, when warmed and made neutral and evaporated to dryness, yields * soluble gluside ’ or ‘ soluble saccharin,’ which is very soluble in water, one hundred parts of gluside yielding nearly one hundred and thirteen of neutral ‘ soluble gluside.’ On fusing writh caustic soda, dissolving in water, faintly acidulating with hydrochloric acid, and adding a few drops of solution of perchloride of iron, a reddish-brown or purplish colour is produced. Non-Official Preparations.—Elixir Saccharini. Saccharin, 24 grs.; Bicarbonate of Sodium, 12 grs.; Rectified Spirit, 1 dr.; Distilled Water, 7 dr. 20 min. contain 1 gr. of saccharin. Tabellse Saccharini. Each contains | gr. saccharin with bicarbonate of sodium. Action and Uses.—To sweeten food instead of sugar in cases of diabetes and to render medicines more palatable. The tabellae (non-official) are convenient for sweetening tea, coffee, or lemonade in diabetes. About ^ of a grain of saccharin or 20 minims of the elixir per ounce is sufficient to flavour mixtures containing bro- mide or iodide of potassium or ammonium, chloride of ammonium, salicin, salicylate of sodium, cascara sagrada, nux vomica or strychnine. Even this quantity is too large for many patients, who complaiij of the persistent sweetness remaining in the mouth. Although there was at one time a great outcry about the dangerous properties of saccharin, there is no satisfactory evidence of its being more injurious than sugar, even when taken in large quantities and for long periods. Its excessive use has produced dyspepsia, but sugar is liable to the same objection. Like other bodies of the aromatic series it has an antiseptic tendency and has been used to prevent decomposition of the urine in chronic cystitis (p. 446). Narcotics and Hypnotics. We have three narcotic additions. Two of them, paralde- hyde and sulphonal, are new and useful hypnotics, made artificially, and frequently employed instead of opium or its preparations to produce sleep. But we have no drug yet of synthetic origin which has such a universal and powerful action as morphine in relieving pain and causing sleep, although phenazone and its congeners to a certain extent replace it as an analgesic, and paraldehyde and
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