Hæmatoporphyrinuria and its relations to the source of urobilin / by David Fraser Harris.

  • David Fraser Fraser-Harris
Date:
[1897]
Catalogue details

Licence: Public Domain Mark

Credit: Hæmatoporphyrinuria and its relations to the source of urobilin / by David Fraser Harris. Source: Wellcome Collection.

Provider: This material has been provided by The University of Glasgow Library. The original may be consulted at The University of Glasgow Library.

    5/6 (page 389)
    of urobilin or pathological urobilin, which also occurs in acute muscular rheumatism and in other fevers. [The presence of an increase of urobilin in febrile urine may possibly be due not only to an excessive initial production of pigment-antecedent normally oxidised to urobilin, but also to a diminished reduction to chromogen by the relatively inactive renal epithelium.] Tissue, other than hepatic, can katabolise blood-pigment, but urobilin is not always the end-product—the initial reduction' may not proceed so far as that. These other tissues may be included under three heads:— I. muscles; II. skin; III. connective tissues, with bones cartilages, etc. Now, it is of blood from these three systems, in addition to the hepatic supply, that the blood in the right auricle may be chemically viewed as constituted: blood from these four sources contributes to arterial and therefore renal blood. Under certain diseased conditions of one or more of these three systems, urohsematoporphyrin replaced urobilin in the urine, notably in acute rheumatism (muscular and articular), effusion of blood into the peritoneum, and Addison's disease; but the follow ing is a complete list of M'Munn's cases,* with the seats of de- praved metabolism indicated (as above numbered) :— Acute rheumatism (I. and III.) Pericarditis Peritonitis Meningitis Cirrhosis of liver Peritoneal blood effusion Croupous pneumonia. Typhoid fever Measles Addison's disease Hodgkin's disease. Sulphonal overdosing, f (HI.) (II.) The less de-oxidised ally, meio-de-oxyh*matoporphyrin has appeared as tke pigment on one or two occasions-twice £l£ * Journal of Physiology, vol. x. t Oswald, Olas. Med. Journal, 1895.