Vaccinia and variola : a study of their history / by John B. Buist.

  • Buist, John B. (John Brown), 1846?-1915.
Date:
1887
Catalogue details

Licence: Public Domain Mark

Credit: Vaccinia and variola : a study of their history / by John B. Buist. Source: Wellcome Collection.

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    Typical Jeimeriaii vesicle. Establisli- inent of areola. Terniiiia- tion. Choice of material. eighth day, or even earlier, a material which is iden- tical in appearance and potency witli that by which it was originally produced. On the eighth day, the vesicle becomes surrounded by a rose-coloured zone of inflammation or areola, which continues to increase for several days, and the clear contents of the vesicle are then found to be opalescent or opaque. The establishment of this areola is regarded as a proof of the specific effect of vaccina- tion on the constitution. From the eighth to the tenth day, the opacity of the lymph continues to increase, after which coagulation of the contents of the vesicle takes place, with the gradual formation of a dry brown scab by the fourteenth day. This scab becomes harder, drier, and darker during the third week, when it falls off, leaving a depressed, circular or oval cicatrix, which is the natural termination of the process by which the majority of the human race are protected for a lifetime from small-pox. If such a termination to vaccination could be guaranteed with certainty, its beauty and simplicity could not be questioned. The material by which typical Jennerian vesicles arc produced is clear vaccine lymph. It is, however, found in practice that, without various precautions, such uni- form results are difficult to obtain, and groat stress is accordingly laid by authorities on the proper selection of vaccine material. Thus, clear lymph is regarded by the authorities of the National Vaccine Establishment as a perfect material for vaccination, and they dis-
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