On the antagonism between medicines and between remedies and diseases : being the Cartwright Lectures for the year 1880 / by Roberts Bartholow.

  • Roberts Bartholow
Date:
1881
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Licence: Public Domain Mark

Credit: On the antagonism between medicines and between remedies and diseases : being the Cartwright Lectures for the year 1880 / by Roberts Bartholow. Source: Wellcome Collection.

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    duced into the stomach of an. animal, were counterbalanced by the subcutaneous injection of atropia. The account of this ex- periment did not appear until 1867, and was then interpolated in a memoir on the use of Calabar bean in tetanus. During the same year, I was engaged in some experimental investigations on the actions of atropia, and on its antagonists, with a view to the prep- aration of an essay to be offered in competition for the annual prize of the American Medical Association. This essay appeared in the volume of “Transactions” for 1869, and in it I distinctly asserted the existence of the antagonism, and submitted experimen- tal evidence in its support. The following year, the remarkable paper of Professor Thomas R. Fraser* * * § appeared, on the antagonism of atropia and physostigma. In this paper, not only is the an- tagonism established, and its limits defined, but the method pursued is so admirable as to remain the model for all similar investigations. The next study of the physiological autagonism of remedies is that of Professor Preyer, of Jena, the first part of whose elabo- rate treatise on prussic acid appeared in 1868.J In this, and in the second part which appeared two years later, Professor Preyer maintained that the actions of hydrocyanic acid and of atropia were opposed, especially as respects the effect of each on the res- piratory function. This opinion has been much^controverted by Drs. Lecorche and Meuriot, X of Paris; Drs. Hare and Keen, § of Philadelphia ; Professor Schroff, of Vienna; Professor Boehm,|| of Dorpat; and myself.T In a subsequent paper,** Professor Preyer pays his respects to all of us in turn, and maintains his own position with fresh arguments and illustrations. In 1869 MM. Schmiedeberg and Koppe isolated, defined the properties, and studied the antagonisms of muscarine, the alkaloid of agaricus muscarius. They conclude that the effects of muscarine * “ An Experimental Research on the Antagonism between the Actions of Physo- stigma and Atropia.” From tho “ Trans, of the Royal Soc. of Edinburgh,” vol. xxvi, 1872. “Die Blausaure physiologisch untersucht.” In zwei Theilen. Bonn, 1808. $ “ Arch. G6n. de M6d.,” May, 1868, p. 529. § “ Am. Jour, of the Med. Soi.,” vol. lviii, p. 436. [Proc. of the Path. Soc. of Phiia.] I n Uebcr die physiologischen Wirkungen der Blausaure und den angeblichen An- tagonisms von Blausaure und Atropin. “ Arch. f. experiment. Pathol, u. Pharmacol., Band ii, p. 129. Prize Essay. **“Die Blausaure physiologisch untersucht,” Band iii, p. 381.
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