Experience with salvarsan : Ehrlich-Hata's 606 in the New York Skin and Cancer Hospital / Howard Fox and William B. Trimble.

  • Fox, Howard, 1873-1947
Date:
1911
Catalogue details

Licence: In copyright

Credit: Experience with salvarsan : Ehrlich-Hata's 606 in the New York Skin and Cancer Hospital / Howard Fox and William B. Trimble. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

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    G The induration following the insoluble injections varied considerably in the different cases. It was gen- erally well marked for tlie first week. In no case has it absolutely disappeared at the time of writing. In tliree cases (3, 5, 6) it was very severe, accompanied by red- ness and was the cause of considerable discomfort for about two weeks. Xo abscesses occurred, although in one case (G) there was a slight necrosis of tissue, fol- lowed by a serosanguinolent discharge for three weeks. The induration resulting from the soluble injections in the buttocks was e.xtremcly variable in the different cases. It was gi’eatest, as a rule, on the third day after treatment. In some of the cases it was slight and occa- sioned very little inconvenience. Two of the patients, however, complained of considerable lameness for about two weeks. While the ])ain and induration were by no means unbearable they were severe enough to make it very desirable to continue our experiments vvith other methods of injection, concerning which we hope to report in a later communication. The re.=ult of the twenty injections from a clinical standpoint were in some resjiects encouraging, in other disa])pointing. The most brilliant symptomatic result was obtained in Case 13, in which a superficial tuber- culo-crustaceous syphilid disappeared at the end of a month. Even in this case it is not impossible that a single injection of calomel or one or two injections of salicylate of mercury might not have accomplished the same results. An excellent result was also obtained in Case ■>, in which a mild tubercular syphilid of the lip that had existed for twelve years (according to the patient's statement) disappeared at the end of ten days. •V gumma at the sternoclavicular point occurring in the same patient was also healed at the end of a month. In three of the cases (1, 6, 7) presenting early papular syphilids, the results were apparently not so good as those that might have been obtained from mercury. The lesions, however, finally disappeared in each case, and the Wassermann reaction became negative. In three tuberculo-ulcerative cases (3, 10, 15) and in a case of gumma of the phar3mx and palate (14), the results were satisfactory from a clinical standpoint, although the Wassermann reaction has not as yet become negative. The result of treatment in Case 3 was especi-