Genetics for medical students / by E. B. Ford.
- Ford, E. B. (Edmund Briscoe), 1901-1988.
- Date:
- [1961]
Licence: Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
Credit: Genetics for medical students / by E. B. Ford. Source: Wellcome Collection.
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![the blood group polymorphisms 117 Examples: The Kell antigens are: K(A-]-), K(A —); or, if known, K(A+B—), K(A+B + ), K(A-B + ). Both these antigens are dominants. This antigen notation refers to the presence or absence of given antigens on the red cells. It may also be necessary to refer to the antigen itself, such as the presence of an antigen in the saliva (p. 134). In such circumstances, the plus or minus sign is not relevant and can be omitted. Thus it is possible to speak of the K(A) antigen. {iii) Antibodies These are indicated by the locus-symbol with the prefix 'anti' hyphened to it, followed by the gene-suffix in brackets. Example: anti-K(A). iii. the simpler blood groups Though the blood groups included in this chapter are of relatively little clinical importance, owing to the rarity of their antibodies, whether spontaneous or immune, they are of much interest in other fields: those of genetics and ethnology. Moreover, since they are polymorphic, they must, as already explained, be maintained by a balance of selective advantages, though the nature of these is at present unknown. Since even the rarer of the genes involved in controlling them must occupy a considerable proportion of the avail¬ able loci, they can act as useful markers of the human chromosomes (pp. 162-3). The various series in this and the succeeding chapter are arranged in increasing order of complexity, in the light of present knowledge. This should make it easy to understand them. (г) The Duffy System genes: • fy^, fy^. antigens: Fy(A+), Fy(A—); or, if known, Fy(A-f B —), Fy(A+B + ), Fy(A-B + ). antibodies: anti-Fy(A), anti-Fy(B).](https://iiif.wellcomecollection.org/image/b18028639_0126.JP2/full/800%2C/0/default.jpg)
