Genetics in obstetrics and gynecology / Joe Leigh Simpson [and others].

Date:
[1982], ©1982
Catalogue details

Licence: Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)

Credit: Genetics in obstetrics and gynecology / Joe Leigh Simpson [and others]. Source: Wellcome Collection.

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    INDEX / 319 Sexual differentiation disorders of, 158-193 female pseudohermaphroditism, 158-164 gonadal dysgenesis, 176-186 hypogonadotropic hypogonadism, 191-192 Klinefelter syndrome, 186-189 male pseudohermaphroditism, 164-174 polysomies polysomy X in females, 189-190 polysomy Y in males, 190-191 sex-reversed males, 175-176 true hermaphroditism, 174-175 embryologie basis of, 156-158 Short stature syndromes, 48 Sickle cell anemia influence of on reproduction, 37 prenatal diagnosis of, 107 Sickle cell trait, effects of on reproduction, 37 Skin biopsy, fetal, 116 Skin disorders, prenatal diagnosis of, 116 Smoking, effects of on fetus, 257 Spherocytosis, hereditary, 38 Spina bifida, 80 Stein-Leventhal syndrome, 150-151 genetics of, 151 Sterility, radiation-induced, 223-224 Stillbirth chromosomal abnormalities and, 127 genetic counseling after, 100 Streak gonads. See Gonadal dysgenesis Streptomycin, ototoxic effects in fetus exposed to, 252 Sulfite oxidase deficiency, prenatal diagnosis of, 120 Sulfonamides, possible teratogenic effects of, 251 Swyer syndrome, (XY gonadal dysgenesis), 186 Syngamy, definition of, 202 Synteny, definition of, 24 Syphilis, 243-246 clinical manifestations of in mother, 243-244 in neonate, 244-245 diagnosis of, 245 incidence of in mother, 228 in newborn, 243 pathophysiology of, 243 treatment and prevention of, 245- 246 Tay-Sachs disease, prenatal diagnosis of, 120 Telophase, definitions of, in meiosis, 16, 17 in mitosis, 14 Teratogenesis, general aspects. See also Fetal infections; Teratogens; Pregnancy; and specific drugs central nervous system sensitivity in radiation-induced selective, 219- 220 early studies on, 247 in female pseudohermaphroditism, 163-164 timing of agent administration and effect, 163 variability of hormone effects, 163— 164 factors determining effects of, 206- 209 dosage, 206-207 drug interactions, 208 genotype, 208-209 mechanisms of effect, 206, 209 specificity of agent, 206 stage of embryonic development, 207-208 fetal infections causing, 229-246. See also Fetal infections genetic counseling in, 211-212 hyperthermia of nonionizing radiation and, 214 ionizing radiation, effects of, 215- 216, 219-221 long-term effects of, 211 mental retardation, 99 physical agents causing, 211-227 during preimplantation period, 203 proof of, in humans, 210 radioactive isotopes, effect of on, 217-219 relative resistance to during second and third trimesters, 205 ultraviolet light and, 213 Teratogens. See also Drugs; Fetal infections; Radiation