The elements of therapeutics : a clinical guide to the action of medicines / by C. Binz ; tr. from the 5th German ed., and ed., with additions, in conformity with the British and American pharmacopoeias, by Edward I. Sparks.

  • Karl Binz
Date:
1877
Catalogue details

Licence: Public Domain Mark

Credit: The elements of therapeutics : a clinical guide to the action of medicines / by C. Binz ; tr. from the 5th German ed., and ed., with additions, in conformity with the British and American pharmacopoeias, by Edward I. Sparks. Source: Wellcome Collection.

Provider: This material has been provided by the Francis A. Countway Library of Medicine, through the Medical Heritage Library. The original may be consulted at the Francis A. Countway Library of Medicine, Harvard Medical School.

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    (Gerrard, Merck). Internally, as an infusion of 4'0—6*0 grammes (3j.—iss.), tlie leaves produce profuse perspiration and salivation. These symptoms are often accompanied with, nausea and vomiting [and sometimes with collapse]. The action of jaborandi leaves upon the sub-maxillary glands occurs even after division of the chorda tympani, and the sympathetic nerves. Atropia arrests their effect, both on the salivary and the sweat glands. [The direct application of a few drops of a 2 per cent, solution of pilocarpin to the conjunctiva causes strong con- traction of the iris in five to ten minutes, which lasts many hours (Weber, Curschmann). Large doses of pilocarpin reduce the pulse frequency to thirty or even to twelve or eight beats per minute, by stimulating the inhibitory fibres of the vagus in the heart itself (Leyden and Frankel).] The leaves have been clinically tested in a number of cases, in which absorption of various forms of serous effu- sion was desired, but as yet no definite conclusion as to their value is possible. If anything, we may say that the artificial induction of sweating as a therapeutic agent by their means has not completely answered the expectations which they at first excited. A. Weber has, however, recently ob- tained excellent results in a case of oedema of the lungs in croup. The symptoms of asphyxia subsided in three and a half hours after very profuse sweating and sahvation. The dose of hydrochlorate of pilocarpin was 0*02, = gr. i, injected subcutaneously. The child was three years old. [Leyden and Curschmann both report good results with pilocarpin (hydrochlorate) in acute nephritis. 0*03 gramme is a large dose for an adult subcutaneously. In England^ nitrate of pilocarpin has been used in gr. :| doses.]