Therapeutics of syphilis : including preliminary observations with the Ehrlich-Hata preparation, dioxydiamidoarsenobenzol or salvarsan / by Victor C. Pedersen.
- Pedersen, Victor Cox, 1867-1958
- Date:
- 1911
Licence: In copyright
Credit: Therapeutics of syphilis : including preliminary observations with the Ehrlich-Hata preparation, dioxydiamidoarsenobenzol or salvarsan / by Victor C. Pedersen. Source: Wellcome Collection.
Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.
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![Treatment has been mercury and iodide internally. Ad- mitted November 29th; 0.5 gramme of 606 was injected. The result has been an apparent decrease in the shins, es- pecially at one point on the right shin, where a distinct softening and sensitiveness have occurred. As was ex- pected, this was not an ideal case for a remarkable result, but we believe the presence of the pain in his shins justi- fied the injection. The blood pressure in this patient was 117 on admission. Varied from in to 118 while in the hospital and decreased to 105 after discharge. His weight Case ]I.—E L>., presenting ulcerating and scaling lesions ot lower extremities; similar conditions were elsewhere on the trunk. All healed in about four weeks after injection, leaving the usual atrophic scars. Unfortunately the patient returned home before a second photograph could be made. remained the same at 159 to 160 pounds. The serum test was negative on November 28th, December 1st, 5th, and 12th, almost negative on December 19th, and weak on De- cember 27th. Eyes, normal. Case VIII. J. G., married, Spaniard, porter, twenty- nine years old. Admitted to People’s Hospital, December 12, 1910. Diagnosis, syphilis, tertiary stage. Family his- tory, negative. Previous personal history, negative. Syph- ilis acquired twelve years ago. Reasonably good history of mucous patches and alopecia, but not of rash. Gon- orrhoea six years ago. Chief complaint, wife has had seven miscarriages varying from third to seventh month, never went to full term. Several children have been ma- cerated as though syphilitic. Referred to me by Dr. Pli- deyo Noguchi, of Rockefeller Institute, for medical re- search for 606. Injected, December 12th, 0.55 gramme. Ran a variable temperature about ioo° for the second and third days, about 102° on the fourth and fifth days, nor- mal on the sixth day. There was considerable pain, which disappeared when the patient was discharged on the sev- enth day. The blood pressure was highly variable being 155 December 13th and T6th; 152. December 27th; 142, December 15th; 138, December 19th. The serum test on December Toth was strong; December 16th and 17th, pos- itive; December 21st, almost negative; December 27th, very weak. Eyes, normal. There has been slight increase in weight. It is too early to state whether the injection is going to control the syphilis in this patient sufficient to permit his wife to have healthy, living children. Case IX. R. G., the wife of the preceding patient. Spanish, housework; twenty-six years old. Admitted De- cember 12, 19TO, to the People’s Hospital. Diagnosis, syphilis, tertiary stage. Family history, negative. Pre- vious personal history, negative. Venereal disease denied. Can recall no signs of syphilis after marriage. Married eight years, has had seven miscarriages, as previously stated. Is now pregnant possibly for two months. Is m good general condition, and complains of her childless- ness; 0.5 gramme of 606 were injected, December 12th. The patient held the muscles of her buttock very tense so that some of the injection was forced out into the fat where it quickly formed a large node, which at the end of the third week at the present writing seems to be slowly disappearing. Physical examination at the New York Hospital shows that she has a very small fibroid in the anterior surface of the womb, the size of a hazel mu. It is possible that further fibroids within the womb may account for her miscarriages, but they would not ac- count for the syphilization of the children. Blood pres- sure is stated constant at about 105. The temperature rose to 1010 F. on the fifth day after varying previously between 99° F. and ioo° F. and then declined to normal on the seventh day when she was discharged. The serum test on December 12th wbs strong; December 16th, posi- Case XIV.—C. K., showing deep scars of early rupial syphilides. These were ham color, similar to early secondaries just before the third injection and did not change color much after, although a positive became a negative blood test. live; December 17th, almost negative; December 27th, weak. The node referred to above subsequently broke down into a sterile abscess, that is, necrosis of the fat occurred without infection. Case X. S. S., Russian, white, about forty-five years old, male, married, merchant: tertiary syphilis. Referred by Dr. Max Wolper. Chancre of the anus. Acquired about fifteen yegrs ago. At this time he was treated by Dr. Abraham Jacobi. Although his history of secondaries](https://iiif.wellcomecollection.org/image/b2241907x_0011.jp2/full/800%2C/0/default.jpg)
