Thomson's Conspectus of the British pharmacopoeias.

Anthony Todd Thomson

Date:: 1852

Credit: Thomson's Conspectus of the British pharmacopoeias. Source: Wellcome Collection.

145/248 page 117

$charcoal, boil for five minutes, filter, and set to cool, in order that crystals may be formed, which are to be dried on blotting-paper by mere exposure to the atmosphere. The liquor decanted from the crystals will, by further concentration and cooling, yield an additional product. D.) Comp. 2 eq. of quina=329'10+l sulph. aeid=40* 1+8 water=72, equiv. =441-20. 2 (C™, H12, 02, N), SO3, 8 HO. Prop. Crystals colourless, acicular, bitter, inodorous, effloresce in the air. One part requires 740 parts of cold water, 30 of boiling; 80 of cold alcohol for its solution, sp. gr. -850. Soluble in water acidulated with sulphuric acid. If ammonia be added to a solution in acidulated water, quina is precipitated, and the residue, after evaporation, ought not to taste sweet. 100 gr. of disulphate of quinine yield by a gentle heat 8 or 10 gr. of water. At a higher temperature it burns without residue. When freshly prepared chlorine followed by ammonia is added, it becomes green. From 100 gr. dissolved in water acidulated with hydrochloric acid, 26*6 gr. of sulphate of barytes may be obtained by the addition of chloride of barium, and the application of a red heat. Oper. Tonic, antiperiodic. Use. In intermittents; neuralgia; atonic inflammation as erysipelas; strumous ophthalmia ; and debility. It is the best and most certain preparation of bark. Its tendency to produce headache may be coun- teracted by a grain of capsicum. Dose. Gr. ij. to gr. x. in any simple bitter infusion. Incomp. Alkalies and their carbonates, lime-water, salts of baryta, lime, nitrate of silver, and salts of lead. QUINiE MURiAS. D. Muriate of Quinine. {Quince Sulphatis 33-, Barii Chloridi, gr. cxxiij., Aquce distillates f^xxx. Dissolve the chloride of barium in fjij. of the water, and the sulphate of quina in the remainder, raised to the temperature of ebullition. Mix the two solutions, evaporate to one-half, filter, and continue the evaporation by means of a steam or water heat, until crystalline spiculae begin to appear. The solution is now to be permitted to cool, and the crystals which separate to be dried on blotting-paper. The liquor decanted off the crystals will, by further concentration and cooling, yield an additional product.) Oper., Use, and Dose. The same as the Disulphate. The preparation is more expensive. It is used in the preparation of the valerianate. QUIN^ VALERIAN AS. D. Valerianate of Quinine. {Quince Muriatis 3vij., Sodce Valerianaiis gr. exxjv., Aquce distillatce fjxvj. Dissolve the valerianate of soda in f§ij., and the muriate of quina in the remainder of the water, and the temperature of each solution being raised to 120°, but not higher, let them be mixed, and let the mixture be set by for twenty-four hours, when the valerianate of quina will have become a mass of silky acicular crystals. Let these be pressed between folds of blotting-paper, and dried without the application of artificial heat. Instead of weighing out 3vij. of muriate of quina, and dissolving it in water, as is above prescribed, we may employ the solution of the muriate prepared from %. of the sulphate, as directed in the formulae for Quinae Murias, such solution having been first evaporated to f§xjv. It may be observed here, that should it become necessary to evaporate a liquid containing valerianate of quina, care must be taken that its temperature does not rise higher than 1/0°.) Comp. 1 eq. of quina=164*55-1-1 eq. of Valerianic Acid=94*2+2 eq. of water=18, equiv.=276*75. Prop. Satiny crystallized masses of snowy whiteness. The crystals are octahedrons on hexagonal prisms. Taste bitter, but not disagree- able. Slight odour of valerian. Soluble in water, rectified in proof spirit and oil. The presence of the sulphate may be detected by nitrate of barytes. Oper. Tonic, antiperiodic, antispasmodic.$

Thomson's Conspectus of the British pharmacopoeias.

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