Saccharine, the new sweet product from coal-tar : 300 times the sweetening power of cane sugar, a powerful antiseptic, absolutely non-fermenting, positively harmless to the human system.

Wilson, Salamon & Co.

Date:: 1887

Credit: Saccharine, the new sweet product from coal-tar : 300 times the sweetening power of cane sugar, a powerful antiseptic, absolutely non-fermenting, positively harmless to the human system. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

8/20 page 4

$S-—The sodium sulphonates are now converted into their corresponding sulphonic chlorides by intimately mixing them with phosphorus trichloride, and then passing a current of chlorine over the mixture. ] so:-ONa+ (P^'' + 2C1) = C.H, {^^'.^^ + POCI3 + NaCl Toluene Sulphonic Chlorides. The two sulphonic chlorides—the ortho and the para—are now separated by crystallization, the ortho compound only being able to yield saccharine directly. 6, —The ortho-toluene sulphonic chloride is next converted into the ortho-toluene sulphonic amide by treatment with ammonium carbonate:— { ^0:0 +(NH-). CO.=C.H. { *i^;.NH+NH.C1 + Toluene Sulphonic Toluene Sulphonic Amide. Chloride. H2O + CO2 7. —The ortho-toluene sulphonic amide is now oxidized, pre- ferably by means of potassic permanganate in presence of an alkali:— CeH. { ^l^n, + 30 + NaHO = C.H. | ^O-ONa ^ ,jj,0 Toluene Sulphonic Amide. Sodium Ortho-Toluene. Sulphamido-Benzoate. This latter product is precipitated with dilute mineral acid, when benzoyl sulphonic imide, or saccharine, at once separates out:— { sS-NhI + «° = NaCl + H,0 + QH, { } NH Saccharine. Benzoyl sulphonic imide, or saccharine, as produced upon large scale, is a white amorphous powder, and when subjected$