(1) Notes on colloidon membranes for ultrfiltration and pressure dialysis / by G.S. Walpole. (2) Detection and concentration of antigens by ultrafiltration, pressure dialysis, etc., with special reference to diphtheria and tetanus toxins / by A.T. Glenny and G.S. Walpole.

  • Walpole, George Stanley.
Date:
[1915?]
Catalogue details

Licence: In copyright

Credit: (1) Notes on colloidon membranes for ultrfiltration and pressure dialysis / by G.S. Walpole. (2) Detection and concentration of antigens by ultrafiltration, pressure dialysis, etc., with special reference to diphtheria and tetanus toxins / by A.T. Glenny and G.S. Walpole. Source: Wellcome Collection.

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    process is of considerable importance. One thing is certain and that is that the periodic recurrence of “bad” toxin to which every laboratory is subjected need now no longer be feared. By ultrafiltration followed by pressure dialysis a concentration of tetanus toxin may be effected which should be of considerable practical value, for the disintegration products of the broth materials which accompany the antigen are particularly noxious in this case. These membranes are impermeable to enzymes, but allow to pass secretin, . the pituitary active principle, the co-enzyme of zymase, and the toxic con¬ stituent of Witte peptone. REFERENCES. Baroni (1911). Compt. Rend., 70, 312. Heinemann (1908). J. Biol. Cliem., 5, 27. Pick (1912). Biochemie der Antigene (G. Fischer, Jena). Walpole (1915). Biochem. J., 9, 284.