Report of the Committee of Management and Medical Director : 1947 / Papworth Village Settlement.

  • Papworth Village Settlement (Cambridge, England)
Date:
1947
Catalogue details

Licence: Public Domain Mark

Credit: Report of the Committee of Management and Medical Director : 1947 / Papworth Village Settlement. Source: Wellcome Collection.

    18/26 (page 18)
    Machine Section, Printing Department. avian tubercle bacilli and embryo chicken lung have been continued in conjunction with Dr. H. B. Fell, Director, Strangeways Labora¬ tory. We began a new study infecting gland¬ ular and spleen tissues from adult rabbits with virulent bovine and avian strains in order to discover whether tissues from susceptible hosts respond in the same way to avian and bovine bacilli. Our results indicate that each type has its own specific effect on the tissue culture. (b) Tissue-culture experiments with tubercle bacilli of the human type carried out at Papworth. In view of our findings described under (a) we have decided to undertake a more compre¬ hensive survey on the question of Species Pathogenicity in tissue culture, using avian, bovine and human tubercle bacilli for infection of spleen tissues from rabbits, chickens, rats and guinea-pigs, thus cross-testing the various ' types of mammalian tubercle bacilli with the tissues of naturally susceptible and resistant hosts. For this purpose we decided to divide our efforts and to make simultaneously tissue- culture experiments with the human and bovine strains at Papworth, and the avian and bovine strains at Strangeways. We started tissue-culture work at Papworth with human and avian bacilli in September and hope to be ready for the joint experiment early next year. (c) A comparison of the tissue response in vitro and in vivo. Our findings were suggestive that the mechanism of infection in vivo differed in many aspects from that observed in tissue culture. To prove this fact I have undertaken a series of animal experiments, using facilities granted to us at the Department of Pathology, Cambridge, by Professor Dean, where we still have the use of laboratory facilities. [18]