Some new physiologically active derivatives of choline / by A.J. Ewins.

  • Ewins, Arthur James.
Date:
[1914?]
Catalogue details

Licence: In copyright

Credit: Some new physiologically active derivatives of choline / by A.J. Ewins. Source: Wellcome Collection.

    5/10 (page 368)
    Expekimental. (a) Choline derivatives. Formyl-choline, OH . N(CH3)3CH2CH20 . OCH. The base was obtained by boiling a solution of choline chloride in formic acid (D 1*22) under reflux for three hours. The excess of formic acid was removed by distillation in vacuo. The residue was dissolved in absolute alcohol and converted into the platinichloride bv precipitation with an alcoholic solution of platinic chloride. The precipitate was filtered off and crystallised from hot water in which it is readily soluble. On standing, the crystalline 'platinichloride was obtained in orange-red octahedra. M.p. 255-256°. 0 1131 ; 0-0840 C02; 0-0450 HaO. C = 20-6 ; H=4-5. 0-1087; 0-0313 Pt. Pt = 28-8. Calculated for (N (CH3)3CH2CH20 . OCH)2PtCl6. C = 21-4 ; H=4-2 ; Pt = 29-0. The aurichloride crystallised from hot water in thin golden yellow hexa¬ gonal plates. M.p. 175°. 0-1168; 0-0488 Au; Au = 41*8. Calculated for N(CH3)3CHaCHaO . OCH. AuCl4 ; Au=41-8. Choline propyl ether, OH . N(CH3)3CH2CH20 . C3H7. This was obtained by acting on £>-iodo-ethyl propyl ether [Karvonen, 1909] with alcoholic trimethylamine solution at the ordinary temperature. The crystalline iodide of choline propyl ether separated on standing, and was filtered off, converted into the chloride in the usual manner and then into the platini¬ chloride, which was obtained crystalline from hot aqueous solution. Orange red prisms. M.p. 246°. 0-1205; 0-1197 C02; 0-0626 HaO ; C = 27-l ; H = 5-75. 0-0922; 0-0262 Pt; Pt = 28-4. Calculated for (C8HaoON)aPt Cl6. C = 27-4; H=5-7; Pt = 27-9. Choline ether, OH . N(CH3)3CH2CTI20 . CH2CH2(CH3)3N . OTI. ^-Diiodo- ethyl ether [Sand, 1901] was treated with a slight excess of alcoholic trimethyl¬ amine solution at the ordinary temperature. On standing, the crystalline choline ether iodide rapidly separated, and was filtered off after about twenty- four hours. The iodide crystallises from 95 per cent, alcohol in thin rectangular plates melting at 275°. The sail is very readily soluble in water, but sparingly soluble in absolute alcohol. 0-0736; 0-0781 Ag I; 1 = 57-3. Calculated for C10H26ON2I2 ; 1 = 57-2.