Leptospiral jaundice in dogs (yellows) / by C,C, Okell, T. Dalling, and L.P. Pugh.

  • Okell, C. C. (Charles Cyril), 1888-1939.
Date:
1925
Catalogue details

Licence: In copyright

Credit: Leptospiral jaundice in dogs (yellows) / by C,C, Okell, T. Dalling, and L.P. Pugh. Source: Wellcome Collection.

    25/36 page 25
    Lymphatic glands enlarged and haemorrhagic. Liver enlarged and pale. Haemorrhages in intestines. An intussusception in ileum. No leptospirae could be isolated from this case. Exp. Dog 4.—(Passage Dog 2 through guinea-pig to culture to Exp. Dog 4). Inoculated September 30, 1924, intraperitoneally with 1 c.c, culture grown from liver of infected guinea-pig. Pup appeared well until October 3, 1924, when the temperature rose to 101 -8° F. Anorexia, soft cough, catarrhal discharge from nose and eyes, and constipation. On October 4, 1924, the temperature began to fall and slight jaundice was evident. Jaundice became intense : clay-coloured stools were passed. Depression marked and pain on manipulation. Death occurred on October 8, 1924. Post-mortem.—Jaundice intense and general. Lungs typical. Intestines congested in parts. Lymphatic glands enlarged and haemorrhagic. Leptospirae found in the ground-up lungs and kidneys, but not in liver. Guinea-pigs inoculated with ground-up liver died typically, and leptospirae found in their livers. Exp. Dog 5.—(Passage Dog 3 through culture to Exp. Dog 5). Inoculated September 30, 1924, intraperitoneally with 1 c.c. culture grown directly from liver of Dog 3. Pup developed the typical disease, temperature falling to 98 -4° F. before death on October 9, 1924. Post-mortem.—Jaundice intense and general. Lungs typical. Lymphatic glands haemorrhagic. Liver enlarged and congested. Intestines congested. Questionable forms resembling leptospirae only seen. Exp. Dog 6.—(Passage Dog 4 direct to Exp. Dog 6). Inoculated October 1, 1924, intraperitoneally with 4 c.c, ground-up liver and spleen of Dog 4. This dog, aged about nine months, has never shown any signs of disease and is still healthy. (December 12, 1924). Exp. Dog 7.—(Passage Dog 2 through guinea-pig, through Exp. Dog 3 to Exp. Dog 7). Inoculated October 4, 1924, 4 c.c. ground-up liver Exp. Dog 3 intraperitoneally. Pup perfectly healthy till October 16, 1924, when blood was seen in the stools. Jaundice developed the same evening and temperature began to fall. Death on October 17, 1924, the temperature being 99 -6° F. Post-mortem.—Jaundice intense and general. Liver pale. Spleen congested and enlarged. Large and small intestines showed numerous punctate subserous haemorrhages. Two intussusceptions were pre¬ sent. Lungs typical. Leptospirae could not be demonstrated in this dog after death by direct methods, but a guinea-pig inoculated with ground-up liver died typically with numerous leptospirae in the liver. Exp. Dog 12.—(Passage Dog 6 direct to Exp. Dog 12). Inocu-
    digitised image 1
    digitised image 2
    digitised image 3