Lesions of the central and peripheral nervous systems produced in young rabbits by vitamin A deficiency and a high cereal intake / by Edward Mellanby.

  • Edward Mellanby
Date:
[1935?]
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Licence: In copyright

Credit: Lesions of the central and peripheral nervous systems produced in young rabbits by vitamin A deficiency and a high cereal intake / by Edward Mellanby. Source: Wellcome Collection.

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    LESIONS OF THE CENTRAL AND PERIPHERAL NERVOUS SYSTEMS 173 peripheral systems of animals receiving the carotene-deficient diet described. The groups of nerve-cells examined include those of the dorsal root and the Gasserian ganglia of the peripheral system, and the cells of Clarke’s column, the Purkinje cells, those of the vestibular nucleus and many others in the central nervous system. In this case also, especially in the spinal cord, it is the afferent side which suffers most. In the mid-brain, however, the red nucleus and the dentate nucleus, and sometimes the 3rd nucleus, occasionally show some abnormalities. I wish to express my indebtedness to my technical assistant, Mr. R. C. Stewart, for the great help he has given in this investiga¬ tion, especially by improving histological methods so as to allow a large mass of material to be examined. The expenses of the work were paid by the Medical Research Council, to whom my thanks are due. REFERENCES. [1] Mellanby, E. (a) Journ. Physiol., 1926, 61, xxiv. (b) Brit. Med. Journ., 1930, i, 677. (c) Brain, 1931, 54, 247. (cl) Edinb. Med. Journ., 1933, 40, 197. (e) Journ. Path. Pact., 1934, 38, 391. (/) “Nutrition and Disease,” 1934, Edinburgh, Oliver and Boyd (Croonian Lectures, 1933). [2] Stockman, R., and Johnston, J. M. (a) Journ. Hyg., 1933, 33, 204. Stockman, R. (6) Ibid., 1934, 34, 235. [3] Lorrain Smith, J. Journ. Path. Bad., 1906, 11, 415. [4] Ramon-y Cajar. “ Degeneration and Regeneration of the Nervous System,” translated R. M. May (Oxford University Press, 1928). [5] May, W. Page. Brain, 1906, 29, 742. [6] Mellanby, May and King, J. D. Brit. Dent. Journ., 1934, 56, 2 Binding. [7] Mellanby, May. Sp. Pep. Ser. Med. Res. Coun., Lond., No. 153, 1930. [8] Zimmerman, H. M. Journ Exp. Med., 1933, 57, 215. [9j Nissl, F. Z. f. Psychiatr., 1892, 48, 197. [10] Idem. Zbl. f. Nervenheilk. u. Psychiatr., 1894, n.f. 5, 337. [111 Idem. Z.f. Psychiatr., 1892, 48, 675, and Neurol. Zbl., 1896, 15, 947. [12] Goldscheider, A., and Flatau, E. Fortschr. der Medizin, 1897, 15, 241, 609 and 793. Also Flatau, E. Ibid., 1897, 15, 281. [13] Russell, C. K. Johns Hopkins Hosp. Bull., 1904, 15, 196. [14] Dye, J. A. Quart. Journ. Exp. Physiol., 1927, 17, 71. [15] van Gehuchten, A. Bibliographie anatomique, 1896, referred to in Anatomie clu Systeme Nerveux de Vhomme, 1900, i, 338, by same author. [16] Idem. Anatomie clu Systdne Nerveux de Vhomme, Louvain, 1900, pp. 335-337. [17] Sherrington, C. S. Journ. Physiol., 1932, 75, 11 P. [18] Fulton, J. F., and Sherrington, C. S. Ibid., 1932, 75, 17. [19] Green, H. N. Biochem. Journ., 1934, 28, 25. [20] Dale, H. H., and Gaddum, J. H. Journ. Physiol., 1930, 70, 109. [21] Dale, H. H. Linacre Lecture, Brit. Med. Journ., 1934, i, 335. [22] Elliott, T. R. Journ. Physiol., 1905, 32, 401.