On the nature and physiological action of the Crotalus-poison as compared with that of Naja tripudians and other Indian venomous snakes : also investigations into the nature of the influence of Naja- and Crotalus-poison on ciliary and amoeboid action and on Vallisneria, and on the influence of inspiration of pure oxygen on poisoned animals / by T. Lauder Brunton and J. Fayrer.

  • Brunton, T. Lauder (Thomas Lauder), Sir, 1844-1917.
Date:
[1875]
Catalogue details

Licence: Public Domain Mark

Credit: On the nature and physiological action of the Crotalus-poison as compared with that of Naja tripudians and other Indian venomous snakes : also investigations into the nature of the influence of Naja- and Crotalus-poison on ciliary and amoeboid action and on Vallisneria, and on the influence of inspiration of pure oxygen on poisoned animals / by T. Lauder Brunton and J. Fayrer. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

    5/18 (page 265)
    12.20. Twitehiugs much increased, now mainly in head and neck, not so much in hind legs. 12.28. Gfuineapig quiet, but with occasional twitchings ; sluggish and disinclined to move. 1.30. Sluggish in moving; can still move about, though disinclined to do so. The punctured thigh is very blue. The rest of the notes of this experiment were lost. The animal died. Experiment III. June 10f/t, 1874.—| of a grain of Crotalus- and ] of a grain of cobra- poison were carefully weighed and diluted, each with ten drops of dis- tilled water. Two full-grown guineapigs of equal weight were then selected. The solution of CVotaZits-poison was injected into the peritoneal cavity of guineapig No. 1 at 1.52 p.m. 1.55. Muscular twitchings of head and neck. 2 p.m. Startings and twitchings continue. It gives faint squeaks occasionally, as though the sudden startings which occur at intervals of 5 or 6 seconds cause pain. 2.5. Twitchings continue. 2.8. Very restless; twitchings going on, but no paralysis yet. 2.17. The same. 2.25. Restless and weaker; but still moves freely on being roused. 2.42. Sluggish ; drags the hind legs. 2.58. Weaker; rolls partially over on one side, but can run when roused. 3.3. Lying on side, but can be roused ; is partially paralyzed in hind legs. Respiration abdominal and hurried. 3.5. Nearly quite paralyzed; is roused with difficulty. 3.7. Can still be roused. Abdomen distended and painful; ci’ies out when it is touched, as though peritonitis were setting in. 3.12. Can be roused with difficulty; respiration hurried; convulsive movements of fore legs and neck. Can still stagger for a few paces ; but coordination of muscular power much diminished, 3.30. In violent convulsions. 3.38. Convulsions continue. 3.45. Quiet. Paralyzed ; but reflex action still continues. 3.55. Dead in 2 hours and 3 minutes. 3.50. Electrodes in cord cause twitching of muscles of the back, and very slightly in those of the legs: the cord was evidently all but para- lyzed. Muscular fibre contracts freely to direct stimulus of current. The intestines were ecchymosed and congested. There were effusions of red serum into the peritoneal cavity, and much ecchymosis of peritoneum and subperitoneal and intra-muscular areolar tissue. Peristaltic action continued faintly.