Genetic rearrangements in leukaemia and lymphoma / J.M. Goldman, D.G. Harnden.

Date:
1986
Catalogue details

Licence: Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)

Credit: Genetic rearrangements in leukaemia and lymphoma / J.M. Goldman, D.G. Harnden. Source: Wellcome Collection.

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    66 GENETIC REARRANGEMENTS primates. As the evolutionary distance between species increases, a concomitant increase in the number of chromosomal rearrangements is observed. Some linkage groups have remained together for long periods of evolution. For example, several genes on the short arm of human chromosome 1 (for example, genes for phosphogluconate dehydrogenase, enolase-1 and phosphoglucomutase) are linked in such divergent species as man, monkey, mouse, cattle and sheep^^ Extensive comparison of human to Mus musculus has revealed a number of conserved linkage or syntenic groups. These observations can now be extended to the location of c-oncs. Table 3.2 lists the c-oncs which have been mapped in mouse - all of which have also been mapped in humans. Some of the genes comprise conserved syntenic groups (see Table 3.5), while others cannot be excluded from being in conserved regions because of a lack of suitable markers. Two c-oncs from the src family, c-src and c-abi, reside on the same chromosome in mouse^^^^. However, the two genes appear to reside in different syntenic groups: c-src, which is syntenic with adenosine deaminase and inosine triphosphatase on human Table 3.5 Conserved syntenic groups observed between man and mouse
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