Bacterial action of some organic compounds of mercury / by T.A. Henry, T.M. Sharp, and H.C. Brown.
- Thomas Anderson Henry
- Date:
- [1925.]
Licence: Public Domain Mark
Credit: Bacterial action of some organic compounds of mercury / by T.A. Henry, T.M. Sharp, and H.C. Brown. Source: Wellcome Collection.
6/12 page 516
![Table I. Salts of mercurated hydroxybenzaldehydes, alkyl/phenols and certain related substances in water. Mercurated hydroxybenzaldehydes. Toxicity to B. typhosus K_ Mercury in toxic con¬ centration 0* 0/ 5* /O No. Substance used % kills % fails 1 C6H2[(CHO)(HgOH)2(OH) = 1 : 3 : 5 : 2] 0-0202 0-013 0-016 2 C6H2[(CHO)(HgOH)2(OH) = 1 : 3 : 5 : 4] — 0-03 ♦ 3 C6H3[(CHO)(HgOH)(OH) = 1 : 2 : 3] 0-0085 0-0056 0-005 4 C6H[(CH0)(Hg0H)2(0H)(N02) = 1 : 2 : 4 : 3 : G] 0-06 0-05 0-04 5 C6H2[(CH0)(Hg0H)(0H)(N02) = 1 : 2 or 4 : 3 : 6] 0-01 0-009 0-005 G C6H[(CH0)(Hg0H)2(0H)(N02) = l : 2 : 6 : 3 : 4] 0-02 0-01 0-013 7 C6H2[(CH0)(Hg0H)(0H)(N02) = l : 2 or 6 : 3 : 4] 0-0038 0-0029 0-002 8 C6H[(CH0)(Hg0H)2(0H)(N02) = 1 : 4 : G : 3 : 2] 0-06 0-05 0-04 9 C6H2[(CH0)(Hg0H)(0H)(N02) = 1 : 4 or 6 : 3 : 2] 0-0095 0-0086 0-005 10 C6H2[(CH0)(Hg0H)(0H)(N02) = 1 : 5 : 4 : 3] 0-117 0-095 0-06 Mercurated alJcylphenols. 11 C6H2[(CH3)(C3H7)(HgOH)(OH) = l : 4 : ? : 2] 0-038 0-017 0-021 12 G6H[(CH3)(C3HT)(HgOH)9(OH) = 1 : 4 : 2 : 6 : 3] 0-033 0-016 0-023 13 C6H3[(C4H9)(HgOH)(OH) = l : 3 : 4] 0-043 0-032 0-024 14 C6H2r(C4H9)(HgOH)2(OH) = 1 : 3 : 5 : 4] — 0-012 * 15 C6H3[(C5Hn)(HgOH)(OH) = l : 3 : 4] 0-035 0-028 0-018 16 C6H2[(C5Hn)(HgOH)2(OH) = l : 3 : 5 : 4] — 0-022 * Miscellaneous mercury compounds. 17 Hydroxymercuri-o-nitrophenolf 0-0021 0-001 0-0011 18 Hydroxymereuri-m-nitrophenol 0-005 0-004 0-0028 19 Dihydroxydimercuri-ra-nitrophenol 0-01 0-009 0-007 20 Hydroxymercuriacetylsalicylic acidf 0-6 0-4 0-26 21 Hydroxymercuridibromofluoresceinf 0-3 0-2 0-069 * Strongest concentration possible. f Commercial preparations issued and used as sodium salts. In order to confirm tills result mono- and di-mercuri derivatives of m-nitro- phenol were prepared, when it was found that the dimercuri derivative (No. 19, Table I) is only half as active as the monomercuri compound (No. 18, Table I). On arranging these results as in Table II, to show the percentage of metallic mercury in the concentration toxic to B. typhosus, it becomes clear that the bactericidal equivalent, thus expressed in terms of metallic mercury, depends in a marked degree on the nature of the organic residue to which it is attached. When these effects are considered in detail it is seen that the two groups —CHO and —OH taken together are most effective in the me£a-position to each other and least effective in the para-position. The entrance of a nitro- group when CHO : OH =1 : 3, enhances the effect in position 4 (No. 7) but exerts no influence in positions 2 or 6 (Nos. 5 and 9) though it should be remembered that these compounds are not strictly comparable since the](https://iiif.wellcomecollection.org/image/b30625270_0006.jp2/full/800%2C/0/default.jpg)
