Bacterial action of some organic compounds of mercury / by T.A. Henry, T.M. Sharp, and H.C. Brown.

  • Thomas Anderson Henry
Date:
[1925.]
Catalogue details

Licence: Public Domain Mark

Credit: Bacterial action of some organic compounds of mercury / by T.A. Henry, T.M. Sharp, and H.C. Brown. Source: Wellcome Collection.

    7/12 (page 517)
    •'>17 BACTERICIDAL ACTION OF MEUCUItY COMPOUNDS position of the mercuri-group is not the same in all three. These results diiler from those of Miss de Witt [1921] with mercurated nitrophenols in which the combination HgOH : N02 : OH was much more active thau IlgOll : Oil and was afc its best with HgOH : N02 : OH = 4:2: 1. Table II. No. in Mercury in toxic con¬ centration Table 1 Substance g- % 17 Hydroxymercuri-o-nitrophenol* . 0-0011 7 Hydroxymercuri-4-nitro-3-hydroxybenzaldehyde 0-002 18 Hydroxymercuri-w-nitrophenol . 00028 3 2-Hydroxymercuri-3-hvdroxybenzaldehyde . 0-005 9 Hydroxymercuri-2-nitro-3-hydroxybcnzaldehyde 0-005 5 Hydroxymercuri-6-nitro-3-hydroxybenzaldchydc 0-005 19 Dihydroxydimercuri-ra-nitrophenol 0-007 0 2 : G-Dihydroxydimercuri-4-nitro-3-hydroxybenzaldehyde 0-013 1 3 : 5-Dihydroxydimercuri-2-hydroxybcnzaldehyde 0-010 15 2-Hydroxymercuri-p-iso-amylphenol 0-018 11 Hydroxymercuricarvacrol 0-021 12 2 : 6-Dihydroxydimercurithymol* ... 0-023 13 2-Hydroxymercuri-]p-fer£-butylphenol 0-024 8 4 : G-Dihydroxydimercuri-2-nitro-3-hydroxybenzaldehyde 0-04 4 2 : 4-Dihydroxydimercuri-G-nitro-3-hydroxybenzaldehyde 0-04 10 5-Hydroxymercuri-3-nitro-4-hydroxybenzaldehyde 0-00 21 Hydroxymercuridibromofluorescein* 0-009 20 Hydroxymercuriacetylsalicylic acid* * Commercial preparations. 0-20 Table III. Comparative tests in serum, broth and Medium A water. Water _a_ Kills Substance % Mercury succinimide 0 001 2-Hydroxymercuri-3- 0-0085 hydroxybenzaldehyde 20° (time 5 minutes) Time 24 hours; 37° 0-0005 Fails o/ /o 0-0001 0-005- Kills o/ /o 0-001 0-05 Broth A Fails o/ /o 0-0001 001 Kills o/ /o 0-1 0-05 Serum A 0-0001 0-001 0-0005 0-01 Time 48 hours; 37° 0-0005 0-0001 0-001 0-0005 0-01 Fails of /o 0-01 0-01 0-005 0-005 Mercury in toxic con¬ centration g- % Water 0-0005 Broth 0-0005 Serum 0 05 Water 0-005 Broth 0-03 Serum 0 03 Water 0-0003 Broth 0-0000 Serum 0-006 Water 0-0003 Broth 0-0000 Serum 0-000 In the case of the alkyl phenols the increase of bactericidal activity due to the introduction of mercury residues is much less marked; thus whilst carvacrol, thymol, p-ter^-butylphenol and p-fso-amylphcnol are all toxic to B. typhosus, under these conditions, at a concentration of about 0-03—0-04 %, the activity of the mercury derivatives (Nos. 11-16, Table I) is of about the same order, but owing to the sparing solubility of the salts of these derivatives in water