Clinical potentialities of certain bisquaternary salts causing neuromuscular and ganglionic block / [W.D.M. Paton, E.J. Zaimis].

  • Paton, William D. M.
Date:
[1948?]
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Licence: In copyright

Credit: Clinical potentialities of certain bisquaternary salts causing neuromuscular and ganglionic block / [W.D.M. Paton, E.J. Zaimis]. Source: Wellcome Collection.

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    As a possible substitute for d-tubocurarine chloride, therefore, this G 10 compound merits consideration, since it is both potent and can be antagonized ; it also has the following advantages : (1) it spares the respiration ; (2) it has less ganglionic action ; (3) it has less power of liberating histamine ; (4) it is a simple compound easily synthesized. The C 6 derivative possesses great potency in paralysing autonomic ganglia, although it is inactive in other respects except in very large doses. Its effects, when injected in a dose of 0*1-1 mgm./kgm., are closely similar to those of tetraethylammonium iodide (paralysis of contraction of cat’s nictitating membrane excited by preganglionic stimulation; fall of blood pressure, no longer obtainable after a paralysing dose of nicotine; paralysis of peristaltic reflex of rabbit intestine; paralysis of para¬ sympathetic ganglia of the heart), and have been shown to be restricted to the autonomic ganglia. C 6 differs from tetraethylammonium iodide in its greater potency (ten to twenty times, according to test object), and in its slower onset and three to four times greater duration of action. The C 6 derivative, therefore, offers possibilities of clinical usefulness in such fields as hypertension and vascular disease, whenever tetraethylammonium iodide has too brief or slight an action. Details of the pharmacological investigations will be published in full elsewhere. W. D. M. Paton E. J. Zaimis National Institute for Medical Research, London, N.W.3. Aug. 17. 1 Paton, W. D. M., and Zaimis, E. J., Nature, 161, 718 (1948). 2 Bovet, D., Depierre, F., and de Lestrange, Y., C.R. Acad. Sci., Paris, 225, 74 (1947). 3 Collier, H. O. J., Paris, S. K., and Woolf, L. I., Nature, 161, 817 (1948). 4 Lyons, R. H., et al., Amer. J. Med. Sci., 213, 315 (1947). 5 Gregory, R. A., and Schild, H. O., XVII Inter. Physiol. Cong. Proc., 288 (1947). 6 Macintosh, F. C., and Paton, W. D. M., XVII Inter. Physiol. Cong. Proc., 240 (1947). 1 Barlow, R. B., and Ing, H. R., Nature, 161, 718 (1948). PRINTED IN GREAT BRITAIN BY FISHER, KNIGHT AND CO., LTD., ST. ALBANS