Materia medica and pharmacy : for the use of medical and pharmaceutical students preparing for examination / by W. Handsel Griffiths ; edited, and in part written, by George F. Duffey.

Date:: 1879

Credit: Materia medica and pharmacy : for the use of medical and pharmaceutical students preparing for examination / by W. Handsel Griffiths ; edited, and in part written, by George F. Duffey. Source: Wellcome Collection.

Provider: This material has been provided by the Royal College of Physicians of Edinburgh. The original may be consulted at the Royal College of Physicians of Edinburgh.

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$COMPOUNDS OF BISMUTH. [Bi=210] B. P. Preps. Strength Dose Action and Use BlSMUTHl CarBONAS Carbonate of Bismutli 2(Bi2COft\Il20 — 6 to 20 grs. Astringent, and sedative to alimentary mucous mem- brane TIspd ill irrftflfiv(> dyspepsia, gastralgia, chro- nic vomiting, and diarrhoea of phthisis. Applied locally as a sedative and absorbent in skin affections, leucor- rhoea, and gleet. BiSMUTHI OXIDUM Oxide of Bismuth 5 to 15 grs. Same as the carbonate. BiSMUTHI SrBSITRAS Subnitrate of Bismuth or White Bismuth BiNOi.HjO Trochisci Bis- muthi 2 grs. in each 5 to 20 grs. 1 to 6 Same as the carbonate. PREPARATION. Carbonate of Bismuth. Mix nitric acid (4 ozs.) with distilled water (3 ozs.), and add purified bismuth (2 ozs.) by degrees, to form the normal nitrate (Bi + 4HNO3 = Bi3N03 + NO + 2H2O). When effervescence, due to escape of nitric oxide gas, has ceased, apply for ten minutes a heat approaching that of ebullition, and afterwards decant tlie solu- tion from any insoluble matter that may be present. Evaporate the solution so as to remove excess of acid and concentrate it until it is reduced to two fluid ounces, and add this in small quantities at a time to a cold filtered solution of carbonate of ammonia (6 ozs.) in distilled water (2 pints) constantly stirring the mixture:— 4Bi3N03 + 3N4H igCaOg = I2NH4NO3 -f 2Bi2C05 + 7C0. Collect the precipitate of hydrated oxycarbonate on a calico filter; wash it with distilled water until the washings pass tasteless. Re- move now as muph of the adhering water as can be separated from the precipitate by slight pressure, and finally dry the product at a temperature not exceeding 150°, to avoid decomposition. Subnitrate of Bismuth. Mix nitric acid (4 ozs.) with distilled water (3 ozs.), and add purified bismuth (2 ozs.) by degrees to form the normal nitrate (Bi + 4HN03 = Bi3N03 + NO + 2H20). When effervescence has ceased, apply for ten minutes a heat approaching that of ebullition, and decant the solution from any insoluble matter that may be present. Evaporate the solution until it is reduced to two fluid ounces, and pour it into half a gallon of distilled water; the sijb- nitrate is thus precipitated, while supernitrate of bismuth remains h\ solution:— 5Bi3N03 + 8H20 = 4BiN04, TT20 + Bi3N03. 8HNO3.$