On artificial tuberculosis, and its relation to cellular pathology and the growth of tumours / by James F. Goodhart.

  • Sir James Goodhart, 1st Baronet
Date:
1871
Catalogue details

Licence: Public Domain Mark

Credit: On artificial tuberculosis, and its relation to cellular pathology and the growth of tumours / by James F. Goodhart. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

    4/24 page 4
    selves in detail and minutite, because, omitting to reflect upon the results of our investigations, we did not notice to what end they pointed. Latterly, however, important clinical and pathological facts have been brought forward, helping to point out the relation- ship of tubercle to other morbid products, but additional evidence is still wanting ere it can be rescued finally from the time-honoured category of unorganizable fibrinous exudations. It is my object to bring forward some such evidence in this paper; and though the ideas embodied in it may not open up any new line of thought, they will, I think, inasmuch as they are the result of independent experiment and observation, strengthen somewhat the position of those who have already pushed the doctrine of artificial tuberculosis to what must be considered their legitimate conclusions, and help towards obtaining for the tuberculous state its true position in a pathological scheme, as the connecting link, so to speak, when viewed with its surroundings, between various diverse morbid con- ditions. In the first place, then, what is tubercle ? All the older writers on this disease may be classed in three groups; of which one, including Rokitansky, Bennett, Ancell, and Lebert, declares it to be a low formed exudation; a second, to which be- long Williams, Henle, and Addison, that it is a retrograde meta- morphosis of pre-existing tissues ; while MM. Lallemand, Cruveil- hier, and Andral considered it to be a concrete form of pus. Opinions were thus divided till M. Villemin published his Re- searches on the Inoculation of Tubercle, in 1865. Those experi- ments I afterwards repeated myself, making use of blood, pus, tubercular sputa, cheesy matter from tubercular ulcers, cancer juice, etc., for the inoculation. It is quite unnecessary to give a detailed account of these here, now that the results of similar experiments are well known; suffice it to say, that my own observations com- pletely coincide with those of Drs Burdon Sanderson, and Wilson Fox, published after most of mine were made,1 and which show that— 1st, Tuberculosis maybe with certainty produced both in the rabbit and guinea-pig (in the dog also, according to Cohnheim), either by the production of an abscess in any part of the body, by the introduction of foreign matter under the skin, or by injecting pus, tubercular matter, etc., directly into one of the serous cavities. Idly, The new product tubercle is a formation of tissue com- posed of large numbers of lymph-like corpuscles and nuclei em- bedded in alveolar spaces. i Dr Alison, of Edinburgh, had, as early as 1829, published the results of some experiments made by Dr Kay, at the Royal Infirmary, in which the in- troduction of mercury into the trachea of the dog had produced an apparent tuberculosis. In the centre of each tubercle, however, a small globule of mer- cury was found. This probably made the results appear less conclusive than they would have been, had the foreign matter been distant from the secondary tuberculosis; and to this cause may probably be attributed the feet, that these did not awaken that amount of discussion to which they were certainly entitled.
    No text description is available for this image
    No text description is available for this image
    No text description is available for this image