Adaptation in pathological processes / by William H. Welch.

  • William Henry Welch
Date:
1937
Catalogue details

Licence: In copyright

Credit: Adaptation in pathological processes / by William H. Welch. Source: Wellcome Collection.

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    an indisputable fact. There is, however, no con¬ clusive proof of this doctrine, and many facts speak against it. The examples from human pathology commonly cited to support the doctrine that local active hyperaemia incites growth of cells are, so far as I am able to judge, complicated with other fac¬ tors, such as injury, inflammation, or trophic dis¬ turbances. Transplantation - experiments, such as John Hunter’s grafting the cock’s spur upon the cock’s comb, sometimes adduced in this connection, are not decisive of this question, for here a new cir¬ cumstance is introduced which some suppose to be the determining one for all morbid cell-growth, namely, the disturbance of the normal equilibrium between parts. Local active hyperaemia may exist for a long time without evidence of increased growth in the congested part. To say that the hyperaemia must be functional is at once to concede that it is not the sole factor. Experiments from Bizzozero’s labor¬ atory, by Morpurgo and by Penzo, indicate that local hyperaemia due to vaso-motor paralysis, or to the application of heat, favors cell-multiplication in parts where proliferation of cells is a normal phenomenon or is present from pathological causes, but that it is incapable of stimulating to growth cells whose pro-
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