Wounds, with a discussion of what constitutes rational treatment / by Frederic Griffith.

  • Griffith, Frederic.
Date:
1902
Catalogue details

Licence: In copyright

Credit: Wounds, with a discussion of what constitutes rational treatment / by Frederic Griffith. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

    11/30 page 9
    new framework tissue formation by their action of assisting to cover lymph spaces with endo- thelium. Marchand states that fibrin is produced by substances liberated by the death of the white blood corpuscles, that the polynucleated cells are retrogressive in nature and have developed from those with a single nucleus, and that further than this they take no part in the formation of new tissue. Sherrington and Ballance maintain that the cicatrix is formed from the cells of the plasma which are nourished by the protoplasm of the leucocytes. Grawitz considers the so-called dormant cells as being all important in the process of wound repair; these cells which are previously invisible in the basement substance of a tissue become sud- denly visible after an injury to the part, their multiplication giving rise to the embryonic germi- nal tissue from which the new fibrillar tissue of the scar is formed. Ziegler’s and Tillmanns’ theory of the forma- tion of fibrillar connective tissue derived from experiments shows that this tissue develops from the fibroblasts as follows: The formative cells are at first round; enlarging they become in ap- pearance not unlike large, round epithelium, or they become elongated and possess one or more processes which anastomose repeatedly one with another. The number of these large cells in- creasing rapidly, they tend to become packed closely together. The fibrillar tissue is now formed in part directly from the protoplasm of these cells, consequently being of intercellular origin and from a homogeneous ground sub- stance or stroma which had developed previously from the same source. Fibers begin to make their appearance from one or both sides of a cell, or from the extremity or in one of the processes,
    digitised image 1
    digitised image 2
    digitised image 3