Annual report / Department of Public Health, Research Institute and Endemic Diseases Hospital.

  • Egypt. Maṣlaḥat al-Ṣiḥḥah al-ʻUmūmīyah. Research Institute and Endemic Diseases Hospital.
Date:
[1936]
Catalogue details

Licence: Public Domain Mark

Credit: Annual report / Department of Public Health, Research Institute and Endemic Diseases Hospital. Source: Wellcome Collection.

    13/88 (page 3)
    We have not yet been able to find any easy method for the estimation of antimony which could be used on a large scale. (b) In what form is Fouadin excreted in the urine ? To investigate this question the urines passed after the injection of Fouadin were shaken with the following substances and filtered:—- (1) Animal charcoal. (2) Kaolin. (3) Kieselghur. (4) Fullers’ earth. The urines used were acid in reaction. The original urines together with the filtrates were tested for pyrocatechin compounds by the Fecl3 test and for antimony by the Keinsch test. It was found that only by using animal charcoal most of the complex compound giving the pyrocatechin reaction could be remov¬ ed from such urines. In the following experiments 100 c.c. of urine (acid in reaction) were shaken for 10 minutes with varying amounts of animal charcoal (Khalbaum charcoal pro-analysis from bone). The results of the Fecl3 test and of the antimony estimations carried out on such urines are shown in the following table :— Table 1 * Fee] 3 - sb in Mgrms. 100 c.c. urine shaken with 1 gramme charocal +++ 075 „ „ „ 5 grammes. 0-65 JJ 33 33 33 . + 0* 4 1 ^ >> >) X,J 33 . very minute traces 0-35 Original urine . “1—1—h 075 The above experiment was repeated on several urines and all gave similar results. Hence animal charcoal could be used for the removal of almost all the complex compound excreted in the urine while the antimony present is only slightly affected.